Although further research is necessary, our preliminary results support the novel possibility that the IPLD photo-induces chaotic dynamics that modulate complex physiologically reparative bioeffects.
In this note, a wide range of innovation indicators are analysed in order to describe the innovation behaviour of manufacturing firms in LAC using the recently released Enterprise Surveys 2010. The Enterprise Surveys define innovation rates as the share of firms introducing product and process innovations. The survey also measures the proportion of firms investing in research and development (R&D) and filing for intellectual property rights (IPRs). The aim of this note is to understand the main characteristics of innovative firms and to gather new evidence with regard to the nature of the innovation process in the region. Statistics about the performance of LAC firms are provided using different types of indicators to measure firms' innovative behaviour. In particular, differences in innovation performance and effort by country, sector, and key firm characteristics, such as being a multinational or exporter, are explored. Those firms in LAC that are top R&D performers are identified, and the analysis closes with an exploration of firm characteristics that strongly correlate with the probability of being a top R&D performer in the region. JEL Classification: D22, O3, O33, O34
In this paper, we use a combination of bibliometric, social network and econometric approaches to increase our knowledge of how research institutions interact with the private sector in Latin America (LA). We first study recent trends in scientific output and specialization. On average, LA countries have been reducing the gap with the world leading regions. They have also tended to specialize in fields related to economic activities based on natural resources, such as Agricultural and Plant and Animal Sciences. However, collaborations with the private sector remain scarce. In this paper, we have built scientific networks composed by what we define as Research Departments (RD). These RDs belong to universities, research institutes and government agencies. We model the intensity of collaboration of a RD with industry as a function of its size, previous performance, and its position in the LA and national scientific networks. Our results show that the RDs which higher diversity of research partners in their national scientific network work more intensively with industry. Additionally, collaborations with industry are influenced by previous interactions with the private sector.
SUMMARY
The purpose of this study was to evaluate serum levels of TNF‐α, sIL‐2R and distribution of peripheral leucocyte subsets in patients with advanced neoplastic disease undergoing IPLD treatment. Fifteen cancer patients with evidence of persistent disease were further divided in two groups according to outcome at the end of the period of clinical evaluation: group 1 patients were still alive and group 2 patients had died. Our results show: (i) an increase in the initial level of TNF‐α in both groups; (ii) a decrease in TNF‐α levels during the follow up of group I patients; (iii) a significant increase in serum levels of sIL‐2R in patients in group 2 compared with those in group 1; (iv) a progressive and constant increase in TNF‐α levels in group 2; (v) a decrease in CD4+CD45RA+ subpopulation in both groups; (vi) an increase in CD25+ cells; (vii) an increase in CD4+, CD4+ CD45RA+ and CD25+ cells during the follow up of group 2 patients. The data generated here form the basis for further investigations on the use of IPLD as a single agent and in combination with other biological response modifiers in cancer patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.