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Scanning electron microscopy was used to study the reactivity of iron-gall inks with varying iron concentrations. Vegetable extracts with hydrolysable tannins produced stable ink, while the presence of crystal aggregates explained the low reactivity of condensed tannins. This novel archaeometric approach has proved useful in chemical corrosion studies of ancient documents.

Objetivo: desvelar a perspectiva de promoção da saúde dos trabalhadores de Estratégia de Saúde da Família em relação aos idosos rurais. Método: qualitativo, tipo ação participante, com 25 profissionais da saúde, elencados por conveniência em um município da região sul do Brasil. O período de coleta ocorreu de agosto a dezembro de 2019. Análise dos dados por meio dos Círculos de Cultura de Paulo Freire. Foram realizados cinco círculos de cultura, com duração média de uma hora, todos gravados e fotografados. Resultados:  a partir dos dados obtidos após a realização da dinâmica com os participantes, emergiram cinco temas: Adoção de hábitos saudáveis; A família como promotora de saúde; Prevenção de doenças; Atividade Coletiva; e O trabalhador como promotor de saúde. Conclusão: a promoção da saúde na perspectiva dos trabalhadores da estratégia tem suas bases no pilar de mudança comportamental de estilo e qualidade de vida individual.

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Background.Optimal strategy for remission-maintenance therapy in patients with MPO-ANCA associated vasculitis is not established. Defining parameters to guide maintenance therapy is required.Methods.A retrospective cohort study of all patients with MPO-ANCA associated vasculitis (microscopic with polyangiitis and granulomatosis with polyangiitis) and glomerulonephritis (GN) followed at the Mayo Clinic between 1996-2015. Relapse rate, MPO-ANCA status, and remission-maintenance therapies were reviewed. Logistic regression models, Kaplan Meier method and Cox proportional hazards regression models were applied.Results.We analyzed 159 patients with active MPO-ANCA associated vasculitis with glomerulonephritis. Sixty-six (42%) patients had at least 1 relapse, and 52 (33%) relapsed before 60 months. Patients with MPO-ANCA who became persistently negative did not relapse (HR 0.03, [95%CI, 0.002- 0.431], p=0.01). The reappearance of MPO-ANCA was associated with a higher risk of relapse (HR 1.91, [95%CI, 1.109 - 3.293], p=0.020). Immunosuppression was withdrawn in 80 (50%) patients, and this was less likely in those who received cyclophosphamide for remission-induction or in patients with persistently MPO-ANCA positive (OR 0.44, [95%CI,0.228-0.861], p=0.02; OR 0.42, [95%CI,0.213-0.820], p=0.01, respectively). Relapse frequency was not different between patients with persistently positive MPO-ANCA and patients with MPO-ANCA reappearance (44% vs. 39%, p=0.49) irrespective of remission maintenance treatment. Ear nose an and throat involvement (OR 6.10 [95%CI, 1.280-29.010], p=0.02) and MPO-ANCA reappearance (OR 9.25, [95%CI, 3.126-27.361], p<0.001), were independent associated with relapse after treatment withdrawal.Conclusions.Patients persistently MPO-ANCA negative are at low risk for relapse even without remission maintenance therapy. Persistence or subsequent reappearance of MPO-ANCA is associated with an increased risk of relapse. Serial MPO-ANCA determinations can inform the development of remission-maintenance strategies in patients with MPO-ANCA associated vasculitis with glomerulonephritis.

http://lattes.cnpq.br/2485328437776710 RESUMO: Objetivo: identificar os desafios da assistência de enfermagem durante o Prénatal às gestantes portadoras do vírus HIV. Métodos: Trata-se de um estudo de revisão integrativa da literatura, com abordagem quantitativa, com busca realizada entre os meses de fevereiro a junho de 2022 nas bases de dados da Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS) e o Base de Dados de Enfermagem (BDENF) acessados por meio da consulta à Biblioteca Virtual em Saúde (BVS); Medical Literature Analysis and Retrieval System Online (MEDLINE), acessada por meio do portal PubMed;

A necessidade de interação entre os desenvolvedores tem aumentado ao longo das décadas, exigindo esforços para promover uma comunicação efetiva. O feedback é uma ferramenta importante que pode ser aplicada em diferentes ocasiões, incluindo conversas informais e reuniões de planejamento. No entanto, é preciso um ambiente propício para essa prática. Relatamos um estudo sobre percepção dos desenvolvedores quanto à prática de feedback e como ela está relacionada à identificação social dos desenvolvedores com seus times. Os resultados sugerem que a percepção da prática de feedback varia de acordo com a ocasião. Encontramos evidências que a percepção do feedback está correlacionada com a identificação dos participantes com suas equipes.

Background and Aims A significant number of patients with anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) with glomerulonephritis (AAV-GN) still progress to end-stage kidney disease (ESKD, eGFR&lt;15mL/min/1.73m2) despite advances in remission-induction treatment. Method A retrospective cohort study on MPO- or PR3-ANCA positive patients with AAV (MPA or GPA) and ESKD at presentation. Renal recovery, dialysis discontinuation and maintenance in ESKD after standard remission-induction, with or without the use of PLEX were compared. Results We analyzed 166 patients with biopsy proven active kidney involvement and eGFR &lt;15mL/min/1.73m2 at the time of AAV-GN diagnosis. Patients received glucocorticoids with CYC (n = 84) or with RTX (n = 72) for remission-induction, and 49 also received PLEX. The predictors for renal recovery were erythrocyte sedimentation rate, SCr at diagnosis and minimal or mild chronicity changes. We analyzed 71 patients who started dialysis with or without PLEX within 4 weeks from AAV-GN diagnosis. The predictors for dialysis discontinuation were minimal chronicity changes in kidney biopsy at the time of diagnosis (OR 6.138, [95%CI 1.389-27.118],p = 0.017) and focal glomerular involvement (OR 5.017,[95%CI 1.287-19.567],p = 0.020). Predictors for maintenance in ESKD at 12 months included higher serum creatinine (SCr) at the time of diagnosis (IRR 1.086, [95%CI 1.005-1.173],p = 0.037), moderate (IRR 3.797,[95%CI 1.090-13.225],p = 0.036), or severe chronicity changes in kidney biopsy (IRR 5.883,[95%CI 1.542–22.439],p = 0.009). Conclusion In our cohort, kidney recovery, dialysis discontinuation, and maintenance of ESKD in patients with AAV-GN and eGFR&lt;15mL/min/1.73m2 depended on SCr and histologic findings on kidney biopsies at the time of diagnosis and was not affected by the addition of PLEX.