Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the virus causing the COVID‐19 disease. Data regarding the morphological properties of this virus are collected from the literature and then the energy stored in each structural element is calculated with Domalski and Hearing's group contribution method. Viruses, including the Corona viruses, derive all of their energy from the host cell and carry out all of their activities with this energy. SARS‐CoV‐2 construct a vehicle needed for the delivery of its mRNA to other hosts to inflict them with the disease. Upon transfer of the viral RNA to the new host, the remaining parts of the viral structure are discarded. Structural and molecular assessments showed that the chemical formula of SARS‐CoV‐2 virus is C 7,336,852 H 12,384,463 N 1,247,424 O 1,915,357 P 100,231 S 25,084 and its enthalpy of formation is −8.70 × 10 −16 kJ. Comparison of SARS‐CoV‐2 with the other viruses shows that its elemental composition does not like any of the others. The results of this study are expected to improve our knowledge of the thermodynamic properties of this virus.

Bacterial infection is a serious medical problem leading to implant failure. The current antibiotic based therapies rise concerns due to bacterial resistance. The family of antimicrobial peptides (AMP) is one of the promising candidates as local therapy agents due to their broad-spectrum activity. Despite AMPs receive increasing attention to treat infection, their effective delivery to the implantation site has been limited. Here, we developed an engineered dual functional peptide which delivers AMP as a biomolecular therapeutic agent onto calcium phosphate deposited nanotubular titanium surfaces. Dual functionality of the peptide was achieved by combining a hydroxyapatite binding peptide-1 (HABP1) with an AMP using a flexible linker. HABP functionality of the peptide provided a self-coating property onto the nano-topographies that are designed to improve osteointegration capability, while AMP offered an antimicrobial protection onto the implant surface. We successfully deposited calcium phosphate minerals on nanotubular titanium oxide surface using pulse electrochemical deposition (PECD) and characterized the minerals by XRD, FT-IR, FE-SEM. Antimicrobial activity of the engineered peptide was tested *

No abstract

No abstract