The discovery of new molecules with antimicrobial activity, and the understanding of the mechanisms of action, are important strategies against multiresistant pathogens. The positive enantiomer of α-pinene appears as an alternative to combat them, since it inhibits the growth of microorganisms, including strains of S. aureus, which gives the possibility of its use as an antimicrobial agent, isolated or in combination with other drugs. Therefore, the main goal of this study is to evaluate the modulating effect of (+)α-pinene on the activity of synthetic antimicrobials that act on protein synthase and interfere with bacterial genetic material. The
The growing number of resistant bacteria is considered a worldwide public health problem. In this context, several control initiatives have been proposed, such as the elaboration of medicines from vegetable raw material as an alternative to fight against microorganisms such as Escherichia coli, which is related to approximately 50% of hospital infections. α-Pinene is found in the oils of many coniferous tree species and has antimicrobial activity against some microorganisms. The positive enantiomer of this compound (+)-α-pinene (+ AP), also called 4,6,6trimethylbicyclo [3.1.1] hept-3-ene, obtained from the company Sigma-Aldrich do Brasil Ltda. The solutions were dissolved in 1% Tween 80 and 5% DMSO and sterile distilled water was used to achieve desired concentrations. The tests were performed on the Escherichia coli strain ATTC 25922. To perform the modulation and adaptation tests, discs containing commercial antibiotics (ATM) were used. The modulating action of monoterpene was determined by the disc diffusion method. The antimicrobials Ceftazidime, Amoxicillin, Cefepime and Cefoxitin demonstrated synergism through association with phytoconstituent. For the remaining ATM, there was no statistically significant difference, and the effect of the association was classified as indifferent. It is concluded that
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