Modulating effect of (+) – α – pinene on the activity of antimicrobials that interfere on protein synthesis and bacterial genetic material

Abstract

The discovery of new molecules with antimicrobial activity, and the understanding of the mechanisms of action, are important strategies against multiresistant pathogens. The positive enantiomer of α-pinene appears as an alternative to combat them, since it inhibits the growth of microorganisms, including strains of S. aureus, which gives the possibility of its use as an antimicrobial agent, isolated or in combination with other drugs. Therefore, the main goal of this study is to evaluate the modulating effect of (+)α-pinene on the activity of synthetic antimicrobials that act on protein synthase and interfere with bacterial genetic material. The