Five new oxygenated pimarane diterpenes, named scopararanes C–G (1–5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1–5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1–5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.

No abstract

No abstract

No abstract

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5β-furost-Δ 25(27) -en-1β,2β,3β,4β,5β,7α,22ξ,26-octaol-6-one-26-O-β-D-glucopyranoside (1) and 5β-furost-Δ 25(27) -en-1β,2β,3β,4β,5β,6β, 7α,22ξ,26-nonaol-26-O-β-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 μg/mL.

Novel non-aggregated boron-fluorine derivatives with large Stokes shift were facilely synthesized and characterized. These dyes show moderate absorptive coefficients and intense fluorescence emission, and excellent photo-stability in solvents and also in solid state. According to X-ray single-crystal analysis, non-covalent intermolecular interactions provide a rigid structure, which inhibits aggregate formation. These non-aggregated dyes can generate singlet oxygen under light irradiation, which makes them good candidates for photodynamic therapy.

Two new polyketides, 7,8-dihydroxy-3,5,7-trimethyl-8,8a-dihydro-1H-isochromen-6(7H)-one (1) and 6-(hydroxymethyl)-2,2-dimethyl-3,4-dihydro-2H-chromene-3,4-diol (2), together with a known nitrogen-containing polyketide (cytochalasin-type of metabolites), [12]-cytochalasin (3), have been isolated from the fermentation broth of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. The absolute configurations of compound 1 were determined by NOESY analysis and the literature data were compared with circular dichroism (CD) spectroscopy. The cytotoxic effects on MCF-7, NCI-H460 and SF-268 cell lines of all compounds were evaluated by the sulforhodamine B method.

No abstract