Background: Breast cancer is the most frequent neoplasm in women. According to American Cancer Society in 2019, an estimated 268,600 new cases of invasive breast cancer was diagnosed among women in USA. In Bangladesh, breast cancer has rapidly become the number one cancer in female pushing cervical cancer to second position. Objective: To evaluate histopathological diagnosis and determination of grades and stages in breast cancer. Methods: This cross-sectional descriptive type of study was conducted in the Department of Pathology, Rajshahi Medical College. Forty-five untreated cases of breast cancer were included in this study between the period of July 2019 to June 2021 and paraffin embedded sections were obtained from representative mastectomy specimen. The sections were stained with hematoxylin and eosin stain followed by evaluation of angiogenesis by using CD34 antibody. Results: According to histopathological grade 51.1% belonged to grade III followed by 28.9% grade II and 20% grade I. Histological stage showed most of the cases was stage II (48.9 %) followed by stage I (26.7 %) then stage III (24.4 %). Upon statistical analysis, a significant relation was obtained between MVD with increasing histologic grades and stages. Conclusion: In conclusion we can say that histological stage showed most of the cases was stage II followed by stage I then stage III.
Background: Angiogenesis is a basic process that enables neoplasm to thrive. Microvessel density (MVD) evaluation is an accepted parameter for assessing the angiogenesis process within a tumour. The research was focused to evaluate angiogenesis by using CD34 immunomarker in invasive breast cancer and to correlate the microvessel density with grades and stages. Objective: To determine microvessel density by CD34 immunoreactivity in female breast cancer and its relation with grading and staging. Methods: This cross-sectional descriptive type of study was conducted in the Department of Pathology, Rajshahi Medical College. Forty-five untreated cases of breast cancer were included in this study between the period of July 2019 to June 2021 and paraffin embedded sections were obtained from representative mastectomy specimen. The sections were stained with hematoxylin and eosin stain followed by evaluation of angiogenesis by using CD34 antibody. Results: In this study, most of the patients (71.1%) belonged to age < 50 years where the mean age was found 47.5 + 12.4 years. In 45 cases, tumour sizes ranged from 1-8 cm. 86.7% (39 cases) ranges from 0-5 cm, where only (6 cases) 13.3% were more than 5 cm. About 30 cases (66.7%) lymph nodes were positive for metastasis. According to histopathological grade 51.1% belonged to grade III followed by 28.9% grade II and 20% grade I. Histological stage showed most of the cases was stage II (48.9 %) followed by stage I (26.7 %) then stage III (24.4 %). Upon statistical analysis, a significant relation was obtained between MVD with increasing histologic grades and stages. Conclusion: As a new prognostic marker it would be of great value in diagnosis and in identifying patients at high risk of tumor recurrence more accurately. By this way breast cancer patients might be benefited from adjuvant therapies.
Background: Enteric fever affects more than 11 million children and adults globally each year. Typhoid fever is treated with antibiotics. Ideally, treatment should be safe and available for adults and children in shortened courses of 5 days, cause defervescence within 1 week, render blood and stool cultures sterile, and prevent relapse. Objective: To compare the outcome of azithromycin and ciprofloxacin for treatment of uncomplicated typhoid fever. Method: This comparative intervention was done at tertiary hospital where one hundred patients ranging in age from 5 to 25 years were enrolled in the study and randomly assigned to one of the two treatment groups. Group A constituted of 50 patients receiving azithromycin and group B constituted of the other 50 patients receiving ciprofloxacin. All patients underwent blood cultures or stool cultures from which S. typhi or S. paratyphi was isolated, and these subjects comprised the basis for analysis. Results: During the study, majority of the patients belonged to 5-15 years age group. 50% cases lived in semi pucca buildings followed by 70% drank supply water without boiling and 80% cases were accustomed to homemade food and outside food. Moreover, significance association was noticed in food habit and water source of the patients. In group A, 50 cases showed positivity in salmonella typhi and their mean duration of hospital stay was 10 days. Similarly, in group B, 50 cases showed positivity in salmonella typhi and mean duration of hospital stay was 9.0 days. In group A, 90% were cured by day 7 plus no relapse cases were found. In group B, 80% were cured by day 7. Mild-to- moderate adverse events, all of which were short-term and self-limited were reported equally in both treatment groups. Conclusion: Our results indicated that azithromycin and ciprofloxacin were similarly effective, both clinically and bacteriologically, against typhoid fever caused by both sensitive organisms and MDR S. typhi.
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