Introduction Monkeypox is a zoonotic Orthopox virus of the Poxviridae family. The general public should be well-informed about monkeypox to prevent the disease in the community effectively. Objective The study aimed to determine the public awareness level about monkeypox among the general community to provide information regarding future measures. Materials and Method The study's design was a cross-sectional observational study. From May to June 2022, a nationwide survey was conducted from Bangladesh's eight administrative divisions. Data were collected from participants through a semi-structured questionnaire, and using Cochran's formula determined the sample size. Data were collected via face-to-face interviews and analyzed using IBM SPSS v.25. Result Among the total of 1,711 respondents to the questionnaire, about 66.6% of the respondents (N=1139) were aware of monkeypox. Among those that were aware of monkeypox, almost two-thirds of the (66.6%) respondents had insufficient knowledge about the transmission pathways (0.71±0.73), vaccination (0.09±0.27), and the signs and symptoms of monkeypox (1.91±1.50). The majority of participants were unable to select the treatment of monkeypox (0.22±0.59). The factors affecting the knowledge level of monkeypox were educational status and occupation (p<0.001). Conclusion The general community has a minimal understanding of the spread of monkeypox and its prevention. This virus requires additional research on its epidemiology, ecology, and biology in endemic regions to be comprehended and prevented.

Hemoglobin A1C (HBA1c) represents the average serological sugar status of T2D patients of the past three months, considered a clinically standard method of studying sugar metabolism. Overexpressing HbA1 can metabolically forecast the risk of different cancers among T2D patients. Based on this, the study aimed to analyze the impact of sugar metabolism in cancer development considering the overexpression of HbA1 as the prognostic biomarker of screening the risks of eight different cancers among the chronic male T2D patients of Bangladesh. Serological analysis of the concentrations of FBS, THABF, creatinine, SC, STGs, HDLC, and LDLC of the T2D patients was conducted in response to their individual HbA1c concentration. Afterward, HbA1 overexpression and promotor-methylation responsible for BLCA, BRCA, CHOL, COAD, LUAD, LUSC, PAAD, and PRAD cancers in the male T2D patients were profiled as the oncoinformatic screening, where the sample types used, individual cancer stages, racial-footprints, gender, age, nodal metastasis, p53-methylations, pancreatitis, diabetes status, smoking behaviors, and survivability status were studied. Finally, the genetic involvement of a group of genes responsible for genetic co-expression of HbA1, endophytic vesicle regulation, antioxidant regulation, and reactive oxygen species based-metabolic regulation in T2D males was identified and comprehensively discussed. The research revealed a significant correlation between BMI and FBS in both the patient and the control groups (p<0.0001). Besides, FBS, THABF, and creatinine were found significantly regulated with their respective HbA1c concentrations (p<0.0001) for each group. The SC, STGs, HDLC, and LDLC regulated ardently and equally for both groups (p<0.0001), while HbA1c ranged from 3.8-5.8% and 5.11-15.8%, for the controls and patients respectively. HbA1 was found interactive with diversified cancer-causing genes, while HbA1 was mostly downregulating with the progressing metastasis. To receive maximum benefits from using HbA1c in clinical profiling of cancer risks among chronic-male T2D patients in minimal time and expense further studies can be needed with a larger sample size.

The Rohingya population are being exiled form Myanmar during several humanitarian crises since 1978 with a recent spike in 2017. Reportedly, the violence, persecution and trauma have posed grievous impacts on the mental health of these forcibly displaced people. This scoping review aims to synthesize the evidence regarding overall epidemiologic burden of psychological problems of Rohingya refugees with their associated factors. We evaluated five major databases and additional sources till 08/05/2022 and included articles according to the eligibility criteria following the Joanna Briggs Institute (JBI) guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. Out of 331 citations retrieved from multiple sources, we included 24 articles in this review. Most of the articles reported high prevalence of different psychological symptoms of Rohingya refugees, such as, depression, anxiety, post-traumatic stress disorder, persistent complex bereavement disorder, feeling of afraid etc. Several correlates of mental health problems were reported, including older age, female, illiteracy, experiences of torture, sexual violence, unemployment, food insecurity, statelessness, separation from family, lack of healthcare access, overcrowded and unhygienic campsites, preexisting health problems etc. There is huge gaps in community level intervention studies, however, Group Integrated Adapt Therapy (IAT-G) and Mental Health and Psychosocial Support (MHPSS) services are widely used. The available evidence suggests a huge burden of mental health disorders with several biopsychosocial factors that may assist in better policymaking and implementation of multilayered approaches like improving healthcare access, training healthcare providers, more community-based intervention studies, and introducing tele-mental health services for Rohingya refugees.

This research aimed to figure out the applications of HbA1c protein and HbA1 gene as the prognostic biomarkers for assessing the risks of different cancers among male T2D patients in Bangladesh considering their serological and oncoinformatic parameters. Depending on the concentrations of HbA1c (%) of the T2D patients (n=300), their individual FBS (mmol/L); THABF (mmol/L); creatinine (mg/dl); SC (mg/dl); STGs (mg/dl); HDLC (mg/dl); and LDLC (mg/dl) were estimated. The values of the patients were compared with the control (n=60) group as the serological analysis. Besides, HbA1 gene (encoding hBA1c protein) overexpression and promotor methylation responsible for BLCA, BRCA, CHOL, COAD, LUAD, LUSC, PAAD, and PRAD cancers in the male T2D patients were profiled as the oncoinformatic parameters based on the sample types; caner stages; racial footprints; gender; age; nodal metastasis; p53 methylations; pancreatitis; diabetes status; smoking behaviors; and overall/disease-free survivability. Finally, the &lsquo;HbA1 gene strings&rsquo; responsible for genetic coexpression; endophytic vesicle regulation; antioxidant regulation; oxygen species metabolic regulation; and gene-mediated response to the reactive oxygen molecules were studied comprehensively. A strong correlation between BMI and FBS was observed in both the patients and the control (P&lt;0.0001). Similarly, the values of FBS, THABF, and creatinine resulted in equal significance (P&lt;0.0001) as compared to the HbA1c concentrations of all the T2D and control individuals. The SC, STGs, HDLC, and LDLC concentrations regulated ardently in both the control (P&lt;0.0001), and patients group (P&lt;0.0001), while HbA1c ranged from 3.8-5.8%, and 5.11-15.8% respectively. HbA1 gene is found downregulating with cancer progressed in most of the oncoinformatic parameters. According to the DA, CS, EI, CE, PC, NC, GF, H, and AT profiles; the HbA1 gene interacts with 8 other genes responsible for creating a protein cluster comprising- AHSP, HBA1, HBA2, HBB, HBD, HBE1, HBG2, RPS12, and RPS19 proteins for cancer formation. To recapitulate, HbA1c protein and HbA1 gene can be used as the prognostic serological and molecular biomarkers respectively for determining the risks of cancers among male chronic T2D patients.