Diabetes has been found to be associated with low levels of thiamine stores in the body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of thiamine has been found in both type I and type II diabetic patients. It has been shown that high-dose thiamine therapy may have a therapeutic effect on early-stage diabetic nephropathy. The aim of this study was to evaluate various biochemical parameters and serum thiamine levels in type I and type II diabetic patients and compare them with a healthy control group.
Background/Aim Diabetes Mellitus (DM) is one of the important public health issues worldwide. The Fat mass obesity (FTO) gene rs-9939609 variant identified single nucleotide polymorphism (SNP) with the T to A missense mutation, and has a strong association with T2DM. FTO gene is present on chromosome “16q12.2” comprising of nine exons. FTO gene rs-9939609 a variant is commonly found in the Pakistani Population. The purpose of the study was to alert the population about the rs-9939609 variant SNP, having a strong association with T2DM. Material and Methods Total of 190 participants were included in the present cross-sectional study. To collect the samples non-probability convenience technique was used. subjects were recruited and divided into three groups, normal healthy subjects, obese and T2DM. The patients were selected from the Medicine department Jamshoro/Hyderabad by filling the pre-designed proforma, as well as verbal and written consent taken from study participants. To analysed the data ANOVA Post hoc (Tukey-test) was applied for comparison among groups (P < 0.05) and “SNP-STAT” online software was used for frequencies. Results The BMI, neck circumference, waist circumference and lipid profile, fasting blood sugar and HbA1c was found significant (p < 0.001) in both genders as compared to control. Homozygous and heterozygous distribution of allelic and genotyping frequency was found in study participants. 37.9 %T/A, 57.4% T/T, and A/A were 4.7%. The FTO gene rs-9939609 variant amplified and have an increased risk of developing T2DM in the Sindh population. Codominant model odd ratio of T/A showed 2.42 ( CI) 1.23–3.84, with significant p < 0.032. Conclusion The present study concluded that the FTO gene SNP rs-9939609 variant was found in the population of Hyderabad, Sindh and having strong association with T2DM and obese individuals. Increase BMI, neck and waist circumference are the biomarkers of obesity and causative factors of T2DM.
English language plays crucial role as an official language of Pakistan and it is applied normally as a medium of instructions crossway over instructional institutions and business organizations. Since anxiety hinders the studying and learning techniques, in this way it's been widely inquired approximately the world and indicates to be underneath seemed into Pakistani context. As a result the important aim of this research is to investigating factors causing language anxiety in learning to speak English in classroom among undergraduate students of Shah Abdul Latif University Khairpur, Sindh, Pakistan. This Study followed a case study with mixed method approach using both quantitative and qualitative tactics. The population of this research study was 214 learners of English from Faculty of social sciences, Departments of Economics, International Relations and Media Studies. In this research study sampling size of 150 students was taken randomly who participated. Questionnaire used “to know students’ level of anxiety was adopted from FLCAS scale, developed by Horwitz et al (1986)”. Qualitative data was also obtained by conducting semi-structured interviews from 15 students randomly from three departments, 5 from each, and classroom observation was also carried out for three weeks. The results showed that anxiety of English classes is high rated Mean=31.98, Secondly fear of negative evaluation Mean=30.62, thirdly communicative apprehension Mean= 25.01 and fourthly test anxiety Mean= 13.89. It indicated that students have problem of anxiety. The statistics was analyzed in element eventually each quantitative and qualitative findings have been mixed to attain the end result of the study. The Findings of study mostly shown anxiety factors in classroom and are prominent such as fear of teacher, other student’s fear of being mocked, fear of making mistakes, lack of confidence, peer pressure, anxious personality, unsure about their abilities, fear of negative evaluation, worry of failing in examination tests, low proficiency, lack of vocabulary. Therefore results are significant that students have problem of anxiety while learning to speak English in classroom.
Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This observational study was carried out at the department of physiology, in affiliation to Medical Research Centre Liaquat University of Medical and Health Sciences Jamshoro. The sample was collected by convenient random sampling. Total 100 participants, 50 controls and 50 obese diabetics were enrolled. Informed written consent was taken from participants. The body mass index (BMI) of the participants was taken at the time of recruitment, and later at 16 weeks of consuming green tea. The serum glucose levels were assessed by fasting (FBS) and random blood sugar (RBS) levels, and HbA1C. The levels of serum Blood glucose were obtained with the glucose oxidase method. Data analysis was done on SPSS 21.0, analysis of variables was done by applying student t-test, the p-value of <0.05 was taken as statistically significant. Results:100 participants recruited out of which 50 controls and 50 obese diabetics men, it was found that the prolong consumption of green tea for 16 weeks with 20-30 minutes’ walk had statistically significant declined in FBS, RBS, HbA1c, and BMI in the obese diabetic subjects, as compared to the controls. Conclusion: This study concludes that the green tea has positive effect in reducing the total body weight and BMI and helps in maintaining the normoglycemic levels in Type 2 DM.
Heart beat is a unit of computing or counting extremity of heart function, whose unit is beat per minute (bpm). Heart has pacemaker cells that creates electrical waves, these cells cause heart rhythm for right atrium with its spread throughout the heart, blood pumping occurs. The human heart naturally break about 60 to 100 bpm, which can vary from condition to condition. Any disorder in heartbeat will lead to heart attack. Which can be detect by human beings by measuring beats. I present a heart rate measuring system which will be first microcontroller system that continuously tracking the beats and wide awake human few months before heart attack. Infrared sensor (RX sensor) will send infrared lights to the body. This sensor has a pair of transmitter and receiver. Using Photodiode (RX sensor) we will detect reflective lights from the body and this signal is sent to the microcontroller which is embedded in the casual wearable (i.e. ring or bracelet etc.) to detect hearth beat. Using this device will generate an alert to the person having increasing cholesterol after before reaching threshold specified for heart attack.
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