Purpose The quality of life (QoL) of patients with type 2 diabetes mellitus (T2DM) is a measure of the successful outcomes of therapy. The program of management of chronic diseases "Program Pengelolaan Penyakit Kronis" (Prolanis) among patients with hypertension and T2DM is a new strategy of the Badan Penyelenggara Jaminan Sosial (BPJS), which is the Indonesian national health insurance system. Here, we analyzed the impact of pharmacist counseling interventions on health-related QoL (HRQoL) in Prolanis T2DM patients. Methods This cluster randomized controlled trial was designed to include two groups [control (n = 111) and intervention (n = 109) groups], and pre-and post-test procedures. The participants were Prolanis T2DM patients who attended four primary healthcare centers (Puskesmas) in Makassar City, South Sulawesi, Indonesia from August 2017 to August 2018. The intervention group received systematic counseling for 6 months. The data were collected using the Bahasa Indonesia version of the European Quality of Life 5 Dimensions 5 Levels (EQ-5D-5 L) questionnaire and were analyzed using EQ-5D preference weight for each health state with the Indonesian EQ-5D-5 L value Set. Furthermore, the EQ-5D index and the EQ-5D VAS score were calculated and HbA1c levels were assessed. Results The change in the EQ-5D-5 L index score (post-pre) was 0.01 in the control group and 0.04 in the intervention group (P = 0.041). The change in the VAS score was −0.07in the control group (post-pre) and 2.66 in the intervention group (P = 0.000). Conclusion Pharmacist counseling may help improve the HRQoL of Prolanis T2DM patients.
This study aims to measure how strong the influence of implementing strategic management practices and digitalization on the performance of micro-enterprises in South Sulawesi-Indonesia (Makassar, Gowa, Maros, & Pare-Pare), especially performance related to sales turnover, break-even point (BEP), and profit. This study uses quantitative methods with primary data and data sources through the interview process and questionnaires. The interview process was conducted with the heads of small and medium enterprises (micro enterprises) in South Sulawesi (Makassar, Gowa, Maros, & Pare-Pare), while the questionnaires were distributed directly to 200 respondents by survey officers. Of the 200 questionnaires distributed to respondents, 180 of them (90%) met the requirements for processing and analysis. The results showed that strategic planning had a negative and significant effect on the sales volume of micro enterprises, strategic planning had a positive and insignificant effect on the bep of micro enterprises, strategic planning had a negative and significant effect on the profits of micro enterprises, implementation strategies had a negative and no effect. significant effect on the sales volume of micro enterprises, the implementation strategy has a positive and insignificant effect on the bep of micro enterprises, the implementation strategy has a negative and insignificant effect on the profits of micro enterprises, strategic evaluation has a positive and significant effect on the sales volume of micro enterprises, strategic evaluation has positive and significant influence on the bep of micro enterprises, strategic evaluation has a negative and insignificant effect on profits of micro enterprises, the use of technology has a positive and insignificant effect on volume Micro-enterprise sales volume, the use of technology has a negative and insignificant effect on the bep of micro-enterprises, the use of technology has a positive and significant impact on the profits of micro-enterprises.
Measuring the quality of life can be used as a reference for the success of an action or therapy as well as initial data in formulating the right action for the patient. This study aims to provide an overview of the quality of life of patients with chronic renal failure who seek treatment at the Hasanuddin University teaching hospital. The research design used was an observational cross-sectional design with data collection carried out by filling out a questionnaire prospectively. The subjects of the study were chronic renal failure patients undergoing hemodialysis who met the inclusion and exclusion criteria and were selected using a non-random sampling technique by means of total sampling. The patient's quality of life was measured using the Kidney Disease Quality of Life Short Form (KDQOL-SFtm) Indonesian version 1.3 questionnaire. A total of 30 patients were willing to participate in this study. The results of the study on 30 patients with chronic renal failure, there were 7 out of 19 scale/item having a not good, namely burden of kidney disease, work status, sleep, physical functioning, role-physical, pain, and general health. The average value of 19 scale/item shows an average score of> 59.37, which is 63.86 which belongs to the good quality of life category.
Statin adalah keluarga obat yang digunakan untuk mengobati hiperlipidemia dengan kapasitas yang diakui untuk mencegah kejadian penyakit kardiovaskular. Pemanfaatan statin secara luas dibatasi oleh adanya toksisitas atau intoleransi terkait, yang mempengaruhi tingkat pemantauan obat. Toksisitas atau intoleransi statin bervariasi dari 10-15%. Gejala otot terkait statin adalah toksisitas statin (SAMS) yang paling umum. Dalam review ini, kami bertujuan untuk melaporkan mekanisme kerja statin yang menyebabkan gejala otot SAMS. Hasil penelitian menunjukkan bahwa statin menyebabkan disfungsi mitokondria akibat adanya stress oksidatif. Mekanisme terjadinya stress oksidatif akibat statin disebabkan karena adanya inhibisi dari protein ubikuinon, aktivasi iNOS, penurunan biogenesis mitokondria, pengurangan fosforilasi oksidatif mitokondria. Secara keseluruhan, data yang dilaporkan dalam tinjauan ini menunjukkan bahwa statin mungkin memiliki efek besar pada fungsi mitokondria terkait stress oksidatif.
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