Millions of nerves, immune factors, and hormones in the circulatory system connect the gut and the brain. In bidirectional communication, the gut microbiota play a crucial role in the gut-brain axis (GBA), wherein microbial metabolites of the gut microbiota regulate intestinal homeostasis, thereby influencing brain activity. Dynamic changes are observed in gut microbiota as well as during brain development. Altering the gut microbiota could serve as a therapeutic target for treating abnormalities associated with brain development. Neurophysiological development and immune regulatory disorders are affected by changes that occur in gut microbiota composition and function. The molecular aspects relevant to the GBA could help develop targeted therapies for neurodevelopmental diseases. Herein, we review the findings of recent studies on the role of the GBA in its underlying molecular mechanisms in the early stages of brain development. Furthermore, we discuss the bidirectional regulation of gut microbiota from mother to infant and the potential signaling pathways and roles of posttranscriptional modifications in brain functions. Our review summarizes the role of molecular GBA in early brain development and related disorders, providing cues for novel therapeutic targets.
Parkinson’s
disease (PD) is the second most progressive
neurodegenerative disorder of the central nervous system in the elderly,
causing motor impediments and cognitive dysfunctions. Dopaminergic
(DA) neuron degeneration and α-synuclein (α-Syn) accumulation
in substantia nigra pars compacta are the major contributors to this
disease. At present, PD remains untreatable with a huge burden on
the quality of life. Therefore, we attempt to explore novel treatment
strategies by detecting effective drugs that stop or arrest PD’s
progression via modifying disease-specific pathways.
Chrysin is a flavonoid derived from passion flowers and possesses
anti-cancer, anti-inflammatory, anti-oxidant, and anti-depression
properties. In the present study, we assessed the neuroprotective
potential of chrysin in transgenic Caenorhabditis elegans models of PD. We observed that chrysin reduced the aggregative toxicity
of α-Syn and diminished DA neuron degeneration induced by 6-hydroxydopamine
(6-OHDA), reduced food-sensing behavioral disabilities, and expanded
the nematodes’ lifespan. Moreover, chrysin augmented the ubiquitin-like
proteasome and superoxide dismutase activities in transgenic C. elegans models. Further, we observed the anti-oxidative
role of chrysin by reducing the internal cellular reactive oxygen
species levels in 6-OHDA-intoxicated C. elegans. Together, these findings supported chrysin as a possible treatment
for PD and encouraged further investigation of chrysin’s mechanism
of action as a neuroprotective medicine in the future.
Parkinson's disease (P.D.) is the second most progressive neurodegenerative disorder in the elderly. Degeneration of dopaminergic (DA) neurons and α-synuclein (α-Syn) accumulated toxicity is the major contributor to this disease. At present, the disease has no effective treatment. Many recent studies focus on identifying novel therapeutics that provide benefits to stop the disease progression in P.D. patients. Screening novel and effective drugs in P.D. animal models is time-and cost-consuming. Rose Essential Oil (REO) extracted from Rosa Rugosa species (R. Setate  R. Rugosa). REO contains Citronellol, Geraniol, and Octadiene that possess anti-Aβ, anti-oxidative, and anti-depression-like properties, but no reports have defined the REO effect on P.D. yet. The present study examines the REO neuroprotective potential in transgenic Caenorhabditis elegans P.D. models. We observed that REO reduced α-Syn aggregations and diminished DA neuron degenerations induced by 6-OHDA, reduced food-sensing behavioural disabilities, and prolonged the lifespan of the nematode. Moreover, REO augmented the chymotrypsin-like proteasome and SOD-3 activities. Further, we observed the anti-oxidative role of REO by reducing internal cells ROS.Together, these findings supported REO as an anti-PD drug and may exert its effects by lowering oxidative stress via the anti-oxidative pathway.
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