Antioxidative role of Traditional Chinese Medicine in Parkinson's disease

Muhammad, Fahim; Liu, Yan; Zhou, Yanjun; Yang, Hui; Li, Hongyu

doi:10.1016/j.jep.2021.114821

Cited by 22 publications

(9 citation statements)

References 193 publications

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“…Parkinson’s disease is another common neurological ailment that results in the degeneration of dopaminergic neurons (which are involved in learning, memory, and motor control) in the substantia nigra, as well as the deposition of inclusion bodies (Lewy bodies) of α-synuclein. , Oxidative damage to neurons is caused by the redox imbalance and the increase in oxidative stress due to quinine formation caused by the alteration of synthesis and the metabolic pathway of dopamine . The mechanisms underlying neuronal degeneration due to oxidative stress in PD are complex and have yet to be fully understood.…”

Section: Effect Of Ros On Aging and Age-associated Diseasementioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.

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Section: Effect Of Ros On Aging and Age-associated Diseasementioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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“…Many traditional Chinese medicines have been reported to possess antioxidant activity ( Muhammad et al, 2022 ). Compared with synthetic antioxidants, herbal components have the advantage of less toxicity, so they have attracted much attention.…”

Section: Pharmacologymentioning

confidence: 99%

Dendrobium huoshanense C.Z.Tang et S.J.Cheng: A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

et al. 2022

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Dendrobium huoshanense, a traditional medicinal and food homologous plant, belongs to the family Orchidaceae and has a long history of medicinal use. It is reported that the stem of D. huoshanense has a variety of bioactive ingredients such as polysaccharides, flavonoids, sesquiterpenes, phenols, etc. These bioactive ingredients make D. huoshanense remarkable for its pharmacological effects on anti-tumor, immunomodulation, hepatoprotective, antioxidant, and anticataract activities. In recent years, its rich pharmacological activities have attracted extensive attention. However, there is no systematic review focusing on the chemical compositions and pharmacological effects of D. huoshanense. Therefore, the present review aims to summarize current research on the chemical compositions and pharmacological activities of D. huoshanense. This study provides valuable references and promising ideas for further investigations of D. huoshanense.

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“…Chinese medicinal herbs are a source of natural antioxidants against oxidative stress or oxidative damage and show great potential for neuroprotection of dopaminergic neurons in the treatment of PD [160,161]. In fact, counteracting oxidative stress is an important strategy to prevent or treat a wide variety of NDs.…”

Section: Tcm Antioxidative Effectmentioning

confidence: 99%

Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine

Sun

Yan

Niu

et al. 2022

Acta Materia Medica

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Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external stimuli, has long been recognized to increase susceptibility to various diseases, including neurodegenerative diseases (NDs). Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, establishes latent infections in the trigeminal ganglia for the lifetime of the host. Upon reactivation, the latent HSV-1 enters the lytic cycle, which not only causes a substantial production of reactive oxygen species (ROS) in the neurons, but also induces glial cells to produce inflammatory mediators, eventually resulting in neuronal damage and occurrence of NDs. Remarkably, both physical and psychological stress are common stimuli leading to latent HSV-1 reactivation. Acyclovir is a classic antiviral drug for the treatment of HSV-1 infection and recurrence, but acyclovir cannot reverse neuronal damage caused by HSV-1 reactivation. Recent studies have shown that traditional Chinese medicine (TCM) has advantages in the treatment of NDs. In addition, TCM is thought to prevent latent HSV-1 reactivation and NDs, which may involve regulation of the neuro-endocrine-immune network, treatment of emotional disorders, and modulation of oxidative stress. Understanding the mechanism underlying stress-induced reactivation of latent HSV-1 and the potential consequences of NDs is needed. TCM may be a promising alternative therapy for related diseases.

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Antioxidative role of Traditional Chinese Medicine in Parkinson's disease

Cited by 22 publications

References 193 publications

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Dendrobium huoshanense C.Z.Tang et S.J.Cheng: A Review of Its Traditional Uses, Phytochemistry, and Pharmacology

Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine

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