Phaleria macrocarpa (Scheff.) Boerl or Mahkota dewa in Indonesia language, a Thymelaeaceae, is widely found in Indonesia, that treat various diseases with satisfactory results. This work reports the results of in silico molecular docking of Phaleria macrocarpa bark compounds through inflammation pathway, because inflammation causes a signaling towards growth and proliferation colon cancer cell, and also testing the cytotoxic activity against HCT116 cell line. Five compounds of bark part of Phaleria macrocarpa were docked against eight inflammation protein. Bark powder of Phaleria macrocarpa was macerated in ethanol for three days, and were concentrated become bark extract. The bark extract then evaluated for cytotoxic activity on HCT116 cell line using MTT method. From the docking result, it showed that the compounds have low Gibbs energy (ΔG) in all inflammation protein. So, the compounds could inhibit the inflammation that causes a signaling towards growth and proliferation colon cancer cell. The bark extract had good IC 50 value compared with Cisplatin as positive control. IC 50 value of bark extract is 20.51 µg/ml. The bark extract of Phaleria macrocarpa is a potential compound to inhibit growth of HCT116 cell line.
Background. Poor sleep and excessive fatigue among workers can reduce well-being and physical fitness. However, not many studies have mentioned how sleeping deprivation among night-shift healthcare workers impacted their work performance in multiple aspects.
Method. We conducted an evidence-based case report (EBCR) of a night shift nurse who was worried about the impact of her sleep deprivation on her work performance in the future due to prior history of needle-stick injuries. We aimed to determine whether sleeping deprivation caused by regular night shifts leads to decreased work performance among night-shift healthcare workers by formulating a clinical question. Evidence was searched systematically using five major journal databases (Proquest, EBSCO-Host, PubMed, ScienceDirect, and Cochrane) and was assessed thoroughly using inclusion and exclusion criteria.
Results. Eleven eligible studies were obtained with a medium level of evidence (III-IV), three systematic reviews with meta-analyses (SR-MA), three SR without MA, and five observational studies. All of them were analyzed and critically appraised using Oxford Evidence-Based Medicine and Joanna Briggs Institute tools. We found that reduced quantity and quality of sleep impacted all dimensions of work performance among healthcare professionals, be it in task performance (e.g., skill proficiency), contextual performance (e.g., communication skill and mental health issues), and patient and health worker safety (accident and medication error). It could also encourage counterproductive work behavior, such as absenteeism. Furthermore, sleep deprivation changes circadian rhythms, causing decreased information processing and affective recognition functions in some vital brain areas, ultimately affecting several work dimensions.
Conclusion. In conclusion, stakeholders need to adjust proper shift scheduling for health care workers, practice sleep hygiene, maintain physical fitness, and consume nutritional food, positively correlated to health and productivity.
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