We present here a brief review of what has been published about fatigue, highlighting its multifactorial nature and the lack of objective markers that make it difficult to establish a consensus on measurement methods and present the Computerized Evaluation of Work Readiness (FOCOS/Prontos System), aiming to assess the correlation between the computerized assessment performance and signs of fatigue, using the Chalder instrument. The study applied the Chalder Fatigue Scale to 552 employees of a Brazilian mining company, with a final sample consisting of 334 individuals divided into a 'clinical group' (G1) with signs of fatigue and a 'control group' (G0) without fatigue. The study aimed to analyze readiness profiles between the clinical and control groups using statistical tests like the Mann-Whitney U-test and Welch's t-test, with significance set at p-value <0.05. Results showed significant differences in daily readiness, cognitive impacts, and risky behaviors before and after self-reporting fatigue. The Prontos System demonstrated predictive value for fatigue-related risks and accident prevention measures, highlighting its role in enhancing workplace safety and productivity. The study highlights the importance of daily and continuous fatigue assessment using the FOCOS/Prontos System to track signs of fatigue, as well as productivity. The system's multidimensional approach enriches fatigue prediction and classification accuracy. Integrating instruments enhances fatigue management, allowing for proactive intervention based on temporal analysis of readiness parameters and behaviors associated with fatigue. The study emphasizes the complexity of fatigue and its correlation with accidents, advocating for ongoing monitoring as a preventive and performance optimization strategy, thus promoting a safer and healthier work environment.