Aims:
This study aimed to improve malnutrition in mice and elderlies with a new dairy/buriti oral dietary supplement.
Background: Malnutrition is a prevalent problem in the elderly; therefore, oral dietary supplementation is an important strategy to reduce the incidence of this health problem.
Objective:
The present study evaluated the effects of a low-cost food supplement, made from by-products of the dairy and fruit industry in the Brazilian Cerrado (Buriti), on the nutritional status and the recovery of the metabolic profile of malnourished animals and elderly women.
Methods:
In the pre-clinical phase, Swiss mice were divided into six groups and subjected to malnutrition and renutrition. The clinical phase was carried out with 25 elderly women residing at a long-term institution, aged ≥ 65 years and with malnutrition or risk of malnutrition.
Results:
The analyzes showed improvements in anthropometric parameters and an increase in serum albumin levels, in addition to lipid profile improvement in the preclinical phase and an increase in the red blood cells and hemoglobin in the clinical phase.
Conclusion:
The supplement based on buriti was able to reverse malnutrition promoting improvements in anthropometric and biochemical parameters.
Background:
Malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates a pro-inflammatory state and increases oxidative stress. The liver is one of the vital organs of our body, so it is necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition.
Aims:
To evaluate the effects of an inexpensive supplementation derived from Buriti and dairy by-products on liver recovery in malnourished mice, focusing on the expression of oxidative stress-related genes, as well as biochemical and histological parameters.
Methods:
Swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed different diets.
Results:
Our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market.
Conclusion:
Our work presents a new composition of low cost food supplement based on buriti and milk derivatives, tested and proven to be effective in the treatment of malnutritvion. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.
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