Sirtuins (SIRTs) are a protein family with high preservation degree among evolutionary scale. SIRTs are histone deacetylases regulatory enzymes of genetic material deeply involved in numerous physiological tasks including metabolism, brain function and aging. Mammals sirtuins comprise seven enzymatic components (SIRT1–SIRT7). The highest studied sirtuin is SIRT1, which plays an essential position in the prevention and evolution of neuro-disorders. Resveratrol (3,5,4-trihydroxystylbene) (RSV) is a polyphenol, which belongs to a family compounds identified as stilbenes, predominantly concentrated in grapes and red wine. RSV is the must studied Sirtuin activator and is used as food supplementary compound. Resveratrol exhibits strong antioxidant activity, reducing free radicals, diminishing quinone-reductase-2 activity and exerting positive regulation of several endogenous enzymes. Resveratrol is also able to inhibit pro-inflammatory factors, reducing the stimulation of the nuclear factor kB (NF-kB) and the release of endogenous cytokines. Resveratrol treatment can modulate multiple signaling pathway effectors related to programmed cell death, cell survival, and synaptic plasticity. In this context, the present review looks over news and the role of Sirtuins activation and resveratrol effects on modulating target genes, cognition and neurodegenerative disorders.
RESUMOObjetivo: descrever as vias de parto a partir dos indicadores de assistência. Método: estudo quantitativo, epidemiológico descritivo, documental, desenvolvido a partir dos indicadores obstétricos neonatais das parturientes atendidas em uma maternidade. O instrumento de coleta de dados foi por meio de consulta aos dados disponíveis por cópias das planilhas do aplicativo Microsoft Excel® 2010. Os dados foram apresentados em tabelas. Resultados: a taxa de parto normal prevaleceu, enquanto a via cesariana foi acima do preconizado pela Organização Mundial de Saúde. Conclusão: achados não diferem de dados encontrados na literatura e evidenciam a necessidade de transformação do modelo de atenção ao pré-natal e ao parto. Descritores: Epidemiologia; Atenção ao Parto; Maternidade; Enfermagem; Parto Normal; Cesárea.ABSTRACT Objective: to describe the delivery routes from the care indicators. Method: quantitative, epidemiological descriptive and documentary study developed from the neonatal obstetric indicators of the parturient women attended in a maternity hospital. Data collection occurred by consulting data available in spreadsheets of the Microsoft Excel® 2010 application. Data were presented in tables. Results: the normal delivery rate prevailed, while the cesarean section rate was higher than that recommended by the World Health Organization. Conclusion: findings do not differ from data found in the literature and show the need to transform the prenatal and delivery care model. Descriptors: Epidemiology; Childbirth Care; Maternity; Nursing; Natural Childbirth; Cesarean Section. RESUMEN Objetivo: describir las vías de parto a partir de los indicadores de asistencia. Método: estudio cuantitativo, epidemiológico descriptivo, documental, desarrollado a partir de los indicadores obstétricos neonatales de las parturientes atendidas en una maternidad. El instrumento de recolección de datos fue por medio de consulta a los datos disponibles por copias de las planillas del aplicativo Microsoft Excel® 2010. Los datos fueron presentados en tablas. Resultados: la tasa de parto normal prevaleció, mientras la vía de cesárea fue más de lo recomendado por la Organización Mundial de Salud. Conclusión: hallados no difieren de datos encontrados en la literatura y evidencian la necesidad de transformación del modelo de atención al prenatal y al parto. Descriptores: Epidemiología; Atención al Parto; Maternidades; Enfermería; Parto Normal; Cesárea.
Aims: This study aimed to improve malnutrition in mice and elderlies with a new dairy/buriti oral dietary supplement. Background: Malnutrition is a prevalent problem in the elderly; therefore, oral dietary supplementation is an important strategy to reduce the incidence of this health problem. Objective: The present study evaluated the effects of a low-cost food supplement, made from by-products of the dairy and fruit industry in the Brazilian Cerrado (Buriti), on the nutritional status and the recovery of the metabolic profile of malnourished animals and elderly women. Methods: In the pre-clinical phase, Swiss mice were divided into six groups and subjected to malnutrition and renutrition. The clinical phase was carried out with 25 elderly women residing at a long-term institution, aged ≥ 65 years and with malnutrition or risk of malnutrition. Results: The analyzes showed improvements in anthropometric parameters and an increase in serum albumin levels, in addition to lipid profile improvement in the preclinical phase and an increase in the red blood cells and hemoglobin in the clinical phase. Conclusion: The supplement based on buriti was able to reverse malnutrition promoting improvements in anthropometric and biochemical parameters.
A hipertensão arterial sistêmica é caracterizada por níveis elevados e sustentados da pressão arterial na qual se configura como um dos principais problemas de saúde pública por se tratar de uma doença crônica, multifatorial e com alto potencial de risco para doenças cardiovasculares, cerebrovasculares e renais. Este estudo objetivou avaliar a qualidade de vida do portador de hipertensão arterial sistêmica assistido por uma Estratégia de Saúde da Família de Minas Gerais. Trata-se de um estudo descritivo, exploratório, transversal, com abordagem quantitativa, realizado com 253 hipertensos cadastrados em uma unidade básica de saúde. Utilizou-se um questionário semiestruturado, adaptado e validado na qual os dados foram apresentados em tabelas. O tratamento dos dados se deu através de análise estatística descritiva simples e análise de correlação empregando-se o teste qui-quadrado. Observou-se maior parte feminina na qual relataram que a hipertensão não afeta a qualidade de vida. O principal fator de interferência na qualidade de vida foi a ingestão de sal (valor p = 0,05), o que demonstrou a importância de se controlar o consumo do mesmo para o controle da pressão arterial e para a prevenção de complicações. A percepção sobre qualidade de vida não se mostrou associada à condição crônica e sim com a postura do indivíduo frente à doença e às mudanças impostas no estilo de vida. O reconhecimento da gravidade da doença e a possibilidade do desenvolvimento de complicações podem ser utilizados pela equipe de saúde como ferramentas auxiliares na educação para a adoção de hábitos de vida saudáveis.
Background: Homeopathy is an alternative therapy that uses substances dilution. The homeopathic preparation of Syzygium jambolanum (SJ) has potential use in the treatment of glycemic disorders. Objective: In this context, the aim of the present study was to evaluate the use of the SJ homeopathic preparation on treating obesity and glycemic/metabolic disorders compared with metformin treatment (diabetes gold-treatment) in a mice model fed a high-fat diet. Method: A total of 48 male Swiss mice were divided into six groups with eight animals each, randomly distributed as follows: obese and non-obese groups (ST), treated and non treated with SJ or metformin. Obesity was induced by high-fat/high-sugar diet, while the control mice (ST) received a standard diet for 12 weeks, after which, for 30 days, the animals received a preparation of 20 µl/100g/body-weight of SJ or a dose of 250 mg/kg metformin (by gavage). The control groups ST and HFHS received water gavage. Body composition and biochemical parameters were evaluated. The adipose genes for lipogenesis and thermogenesis were tested. Results: The mice treated with Syzygium jambolanum presented reduced weight gain (p< 0.02) and smaller adipose tissue weight, average difference from the mice treated with metformin, and both groups showed improved insulin sensitivity (p<0.04). The main results were associated with the modulation of the adipogenesis pathway (C/EPBα and PPARγ) and to the thermogenic gene Uncoupling Protein 1 (UCP1). Conclusion: Homeopathic administration of the Syzygium jambolanum preparation leads to lower body weight, blood glucose and total cholesterol and higher high-density lipoprotein (HDL), pointing its efficiency on treating diabetes and obesity.
Background: Malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates a pro-inflammatory state and increases oxidative stress. The liver is one of the vital organs of our body, so it is necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition. Aims: To evaluate the effects of an inexpensive supplementation derived from Buriti and dairy by-products on liver recovery in malnourished mice, focusing on the expression of oxidative stress-related genes, as well as biochemical and histological parameters. Methods: Swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed different diets. Results: Our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market. Conclusion: Our work presents a new composition of low cost food supplement based on buriti and milk derivatives, tested and proven to be effective in the treatment of malnutritvion. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.