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DelAzulPestRisk is a risk-based chemical ranking model based on human and local biota toxicities that estimates the integrated risk of pesticides in water from their extensive (concentration, risk) and intensive (persistence, bioaccumulation) chemical properties. The model is built on two modules: human health risk factor (estimated based on the probabilistic cancer and non-cancer health risk by using U.S. Environmental Protection Agency models applied to a bathing exposure scenario) and biota health risk factor (quantified on the basis of the probabilistic toxicity exposure ratio -PEC/PNEC-for three local representatives of water biota multiplied by an amplification factor supported by the persistence and bioaccumulation potential). The model was applied to shallow creeks of Tres Arroyos County, Argentina, which flow across wheat and soybean agricultural lands, and in whose waters were detected many organochlorine pesticides (α, γ , y, δ-HCH, aldrin, heptachlor, γchlordane, endosulfan, endosulfan sulphate, dieldrin, and DDD). Dieldrin, aldrin, and heptachlor generated the worst potential effects-due mainly to the cancer and non-cancer dermal health risk-although this was not a significant environmental threat. DelAzulPestRisk is a screening assessment tool for water management purposes that become useful in countries lacking efficient water quality control systems.