Anti-HBs responses in children vaccinated with different schedules of either plasma-derived or HBV DNA recombin`ant vaccine

Determinants of Long-term Protection After Hepatitis B Vaccination in Infancy

“…Conclusions: Based on meta-analyses, predictors of waning immunity after hepatitis B vaccination in infancy could be identified. a prognostic model for long-term protection after hepatitis B vaccination in infancy was developed.Key Words: hepatitis B, infant vaccination, booster, long-term protection, determinants of protection (Pediatr Infect Dis J 2013;32: 307-313) A lthough hepatitis B vaccination is highly effective, vaccination failures leading to acute [1][2][3][4][5] and sometimes chronic infection [5][6][7][8] have been observed. although infections occurring within a short time interval after vaccination are likely to reflect primary vaccination failure 1,4 due to nonresponse, those occurring after decades are likely to reflect secondary vaccination failure due to waning immunity.…”

“…A lthough hepatitis B vaccination is highly effective, vaccination failures leading to acute [1][2][3][4][5] and sometimes chronic infection [5][6][7][8] have been observed. although infections occurring within a short time interval after vaccination are likely to reflect primary vaccination failure 1,4 due to nonresponse, those occurring after decades are likely to reflect secondary vaccination failure due to waning immunity.…”

“…although infections occurring within a short time interval after vaccination are likely to reflect primary vaccination failure 1,4 due to nonresponse, those occurring after decades are likely to reflect secondary vaccination failure due to waning immunity. anti-hepatits B antibodies [anti-HBs] ≥ 10 miu/ ml either after primary vaccination or as response to booster if the antibody concentrations have fallen below are widely accepted marker of protection after hepatitis B vaccination.…”

“…Persistence of anti-HBs ≥ 10 miu/ml and response to booster vaccination 19,21,23 may be related to vaccine dosage, [27][28][29][30] beginning of the primary vaccine regime (at birth or later in infancy), 22,28,29,[31][32][33] timing of the last vaccination of the primary series (ie, the gap time between last and preceding dose), 4,33 numbers of vaccine doses given as primary vaccine series 4 and use of plasma-derived or recombinant vaccines. 4,8,11,19,28,[31][32][33][34][35][36][37] Finally, both parameters may also be influenced by the prevalence of hepatitis B infection in the population and the HBsag carrier status of the mothers in the country.…”

Effect of inclusion of hepatitis B vaccine in childhood immunization program in India: A retrospective cohort study

“…Follow-up studies in several countries have shown that at 5-7 years after the completion of a 3-dose immunization schedule, only 60% to 85% of vaccinees had anti-HBs titer above the commonly-used cut-off of 10 mIU/mL [10][11][12][13][14]. Most of these studies were done in populations with high background rate of transmission of HBV.…”