No abstract

In a retrospective study validated by a standardized clinical and radiological examination, the bone regeneration in 90 patients with cystic mandibular defects was examined. In 50 patients bony defect reconstructions with human demineralised bone matrix (HDBM) were carried out, while in a comparable group of 40 patients the hollow pockets were left to regenerate bone spontaneously. The bone regeneration after the implantation of human demineralised bone matrix (HDBM) was subjected to a comparative validation. Osteoinductive proteins present in HDBM (bone morphogenetic proteins) can diffuse into the implant seat and induce new bone formation (osteoinduction). A markedly faster and more thorough bone regeneration was demonstrated after the surgical therapy of cystic mandibular lesions with HDBM than without. HDBM also proved to be exceptionally biocompatible.

Biocoral is a biomaterial derived from natural corals, and it has surgical applications. Since 1992 the author has been using this material as a bone graft substitute in maxillofacial surgery. Seventy-seven clinical implantations were done for different indications. The results suggest that coral grafts are well tolerated and become partially ossified when the calcified skeleton is resorbed. This material has been demonstrated to be successful.