Biocoral – ein alternativer Knochenersatz

Soost, F.

doi:10.1007/s001040050125

Cited by 15 publications

(6 citation statements)

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“…Coral and nacre, biocompatible and bioactive biomaterials have been often used as bone substitutes for their quality: no transmission of infections like AIDS, hepatitis C [1,2], biocompatibility [3], osteoconduction [4], and high-speed of resorption [5]. Besides, nacre has exceptional mechanical properties attributed to its hierarchical structure [6][7][8] and molecular interactions with the mineral-organic interface [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Physical and chemical characterization of adsorbed protein onto gold electrode functionalized with Tunisian coral and nacre

Hamza

Bouchemi

Slimane

et al. 2013

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Physical and chemical characterization of adsorbed protein onto gold electrode functionalized with Tunisian coral and nacre

Hamza

Bouchemi

Slimane

et al. 2013

Materials Science and Engineering: C

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“…16,19,20,32,35,46,50 Because of their bioactive properties and porous structure, these implants support bone ingrowth as a osteoconductive scaffold and, thus, small defects can even be bridged completely. The formation of a physiochemical compound between ceramic and bone 7,17 is a basic requirement for stable integration.…”

Section: Discussionmentioning

confidence: 99%

Missing osteoconductive effect of a resorbable PEO/PBT copolymer in human bone defects: A clinically relevant pilot study with contrary results to previous animal studies

Roessler

Wilke

Griss

et al. 2000

J. Biomed. Mater. Res.

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PEO/PBT 70/30 (POLYACTIVE(R) 70/30), a degradable porous copolymer with elastic properties, was found to be osteoconductive in many animal studies. The aim of this study was to determine the osteoconductive effect in a human paired control iliac defect model. In seven patients undergoing anterior spinal interbody fusion surgery, two bicortical iliac defects for autograft harvesting were created. The defect size was identical for both defects measuring about 40 x 15 mm (group I). One defect was filled with the degradable implants, whereas the remaining one was left untreated as a control. The defect site for treatment was chosen randomly. In three further patients, only one defect measuring about 40 x 35 mm was created (group II). All patients were examined clinically and radiologically by spiral-CT after 1, 6, 12, 24, and 52 weeks. Three-dimensional reconstructions as well as CT-volumetric measurements using 1 mm sections were used as evaluation methods. In group I, a two-tailed paired t-test showed that the treated defects had significantly less formation of new bone than the untreated ones (p < 0.05 after 12 weeks, p < 0.01 after 52 weeks). Also, in group II, not much bone ingrowth could be observed. The histological evaluation of one patient in group I revealed no bone within the pores, and a fibrous layer between bone and implant was always present. Therefore, PEO/PBT 70/30 cannot be recommended as a bone substitute for clinical use. Differences in bone regeneration between humans and certain animal species as well as inapplicable defect models in previous animal studies are discussed as possible reasons for the failure.

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“…Coral skeletons have been used as bone substitutes in surgery for the last 28 years but it was not until the 1990s that it became commercially available as Biocoral and Interpore [168,169,170,171,172]. A pioneering idea for harnessing coralline materials in medicine came from White et al in 1972 with an innovative process for transforming and generating high fidelity copies of marine skeletons such as coral [51].…”

Section: Biomedical Applications Of Marine Productsmentioning

confidence: 99%

Evolving Marine Biomimetics for Regenerative Dentistry

2014

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New products that help make human tissue and organ regeneration more effective are in high demand and include materials, structures and substrates that drive cell-to-tissue transformations, orchestrate anatomical assembly and tissue integration with biology. Marine organisms are exemplary bioresources that have extensive possibilities in supporting and facilitating development of human tissue substitutes. Such organisms represent a deep and diverse reserve of materials, substrates and structures that can facilitate tissue reconstruction within lab-based cultures. The reason is that they possess sophisticated structures, architectures and biomaterial designs that are still difficult to replicate using synthetic processes, so far. These products offer tantalizing pre-made options that are versatile, adaptable and have many functions for current tissue engineers seeking fresh solutions to the deficiencies in existing dental biomaterials, which lack the intrinsic elements of biofunctioning, structural and mechanical design to regenerate anatomically correct dental tissues both in the culture dish and in vivo.

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Biocoral – ein alternativer Knochenersatz

Cited by 15 publications

References 0 publications

Physical and chemical characterization of adsorbed protein onto gold electrode functionalized with Tunisian coral and nacre

Physical and chemical characterization of adsorbed protein onto gold electrode functionalized with Tunisian coral and nacre

Missing osteoconductive effect of a resorbable PEO/PBT copolymer in human bone defects: A clinically relevant pilot study with contrary results to previous animal studies

Evolving Marine Biomimetics for Regenerative Dentistry

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