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Hospital and laboratory data were analysed in three hospitals to estimate rotavirus disease burden in 1994‐96. Community acquired gastroenteritis was diagnosed in 757 children of whom 41% tested positive for rotavirus. A total of 196 children had rotavirus nosocomial infections (39% of all rotavirus community‐acquired and nosocomial cases) Infants less than 24 months old and children less than 3 months old comprised 74% and 11.9% of admissions for rotavirus, respectively. Almost 94% of children with rotavirus infection had severe gastroenteritis (score 11). The annual rate of rotavirus associated hospitalization in Poland in 1996 was 3.1/1000 children under the age of 60 months and 5.2/1000 infants under 24 months of age. The mean hospital stay was 9.5 d (±9.8 d). We estimated that 8918 children under 60 months of age were hospitalized for rotavirus gastroenteritis in 1996; they accounted for 84899 inpatient days. We conclude that rotavirus is a leading aetiological agent of severe gastroenteritis in young children in Poland and that the Burden of this infection is significant. Rotavirus vaccine could significantly decrease the hospitalization rate and the financial impact of rotavirus Gastroenteritis in Poland. □Acute diarrhoea, disease burden, epidemiology, gastroenteritis, rotavirus

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Helicobacter pylori infection is widely spread all over the world. The prevalence of H. pylori infection in the world varies and depends on numerous factors such as age, ethnicity, geographical and socioeconomic status. Humans have been in a symbiotic relationship with this bacterium for thousands of years. However 10-20% of people infected with H. pylori are likely to develop gastroduodenal diseases such as peptic ulcer disease, iron deficiency anemia, gastric mucosal atrophy, metaplasia, dysplasia, MALT lymphoma, or gastric adenocarcinoma. Most of these diseases develop as the infection progresses and they are likely to occur later in life among the elderly. In the following years, the use of modern molecular techniques has led to the discovery of new Helicobacter strains and their genotypic differentiation. Newly discovered Helicobacter microorganisms can colonize human gastrointestinal tract and bile ducts. This article summarizes the distinct features of H. pylori infection in children including its prevalence, clinical manifestation, indications for treatment and recommended schemes of eradication.

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Resistance to metronidazole (Met), clarithromycin (Cla) and amoxycillin (Amo) was examined using H. pylori isolates from child patients before and after treatment in the period 1997-2001. The rate of Met and Cla resistance before treatment was 35.2 and 8.6%, respectively. Six weeks after treatment 48.4% of the isolated strains were resistant to Met and 17.6% to Cla. The highest rate of resistance to both antibiotics was determined in 2001 (before treatment, 46 and 15%, respectively, and after treatment, 57.8 and 26.3%, respectively). All the strains were susceptible to Amo. Strains resistant to Met were detected more frequently in girls than in boys.

StreszczenieW ostatnich latach ukazały się nowe wytyczne dotyczące rozpoznawania i leczenia choroby trzewnej u dzieci i młodzieży opracowane przez ekspertów ESPGHAN, NASPGHAN i AGA Institute. W pracach tych przedstawiono definicję i klasyfikację choroby trzewnej, wskazania do diagnozowania, aspekty kliniczne, znaczenie badania HLA, badań serologicznych i biopsji dwunastnicy. Przedstawiono także algorytmy postę-powania diagnostycznego z pacjentami z objawami i bez objawów chorobowych oraz algorytm monitorowania leczenia. AbstractIn the last years new guidelines for the diagnosis and treatment of coeliac disease in children and adolescents, developed by ESPGHAN, NASPGHAN and AGA Institute, were published. These publications presented the definition and clas sification of coeliac disease, indications for diagnostic investigation, clinical aspects, importance of HLA and serological investigation as well as duodenal biopsy. The diagnostic algorithm in patients with and without symptoms and the algorithm for treatment monitoring were described.