High level of resistance to metronidazole and clarithromycin inHelicobacter pylori isolated from pediatric patients in Poland (1997–2001)

Gościniak, Grażyna; Iwańczak, Barbara; Przondo-Mordarska, Anna; Grabińska, Joanna; Iwańczak, F

doi:10.1007/bf02931386

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…studied resistance to MET, CLA, and AMO using H. pylori isolates from children before and after treatment. The rate of MET and CLA resistance before treatment was 35% and 9%, and 6 weeks after treatment it was 48% and 18%, respectively . A similar observation was made by Miyaji et al., who concluded that the failure of treatment could be a consequence of the induction of resistance to CLA and MET.…”

Section: Discussionsupporting

confidence: 73%

Antibacterial resistance and the success of tailored triple therapy in Helicobacter pylori strains isolated from Slovenian children

et al. 2017

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BackgroundPrimary Helicobacter pylori (H. pylori) infection occurs predominantly in childhood. Antimicrobial resistance is the leading cause for H. pylori eradication failure. The aims of this study were (i) to establish for the first time the antimicrobial resistance of H. pylori strains in infected Slovenian children not previously treated for H. pylori infection and (ii) to evaluate the effectiveness of tailored triple therapy, assuming that eradication rate with tailored triple therapy will be >90%.MethodsData on all treatment‐naive children 1‐18 years old and treated for H. pylori infection according to susceptibility testing were retrospectively analyzed. All relevant clinical information and demographical information were retrospectively collected from the hospital information systems and/or patients’ medical documentation.ResultsThe inclusion criteria were met by 107 children (64.5% girls) with a median age of 12.0 years (range 2.0‐17.6 years). Primary antimicrobial resistance rates of H. pylori were 1.0% to amoxicillin (AMO), 23.4% to clarithromycin (CLA), 20.2% to metronidazole (MET), 2.8% to levofloxacin (LEV), and 0.0% to tetracycline (TET). Dual resistances were detected to CLA and MET in 11.5% (n=12) of strains, to CLA and LEV in 2.8% (n=3), and to MET and LEV in 2.9% (n=3). Results of treatment success were available for 71 patients (66.2% girls). Eradication of H. pylori was evaluated using the 13C‐urea breath test, monoclonal stool antigen test or in some cases with repeated upper GI endoscopy with histology and cultivation/molecular tests. Eradication was achieved in 61 of 71 (85.9%) patients.ConclusionsThe primary resistance rates of H. pylori to CLA and MET in Slovenia are high. Our data strongly support the fact that in countries with high prevalence of resistant H. pylori strains susceptibility testing and tailored therapy is essential.

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Section: Discussionsupporting

confidence: 73%

Antibacterial resistance and the success of tailored triple therapy in Helicobacter pylori strains isolated from Slovenian children

et al. 2017

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“…The reported resistance of H. pylori in treated children and adults (35-68 % to metronidazole, 17-63 % to clarithromycin and 15-73 % to metronidazole+clarithromycin) can hinder the success of eradication (Chisholm et al, 2007;Gosciniak et al, 2004;Kalach et al, 2007;Koletzko et al, 2006;Toracchio & Marzio, 2003;Tüzün et al, 2008). With the increasing number of prescriptions for H. pylori eradication and the involvement of new treatment regimens, post-treatment resistance to amoxicillin, tetracycline and quinolones has also been reported (Hsu et al, 2008;Koletzko et al, 2006;Nishizawa et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of multidrug-resistant Helicobacter pylori in Bulgaria

Boyanova

2009

Journal of Medical Microbiology

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The aim of this study was to evaluate the presence and prevalence of multidrug antibacterial resistance in Helicobacter pylori in Bulgaria from 2005 to 2008. The resistance in 828 untreated adults, 124 treated adults and 105 untreated children was, respectively, 26.5, 50.8 and 16.2 % for metronidazole; 18.4, 45.2 and 19 % for clarithromycin; 1, 2.4 and 0 % for amoxicillin; 4.4, 10.6 and 1.9 % for tetracycline; and 9, 14.5 and 5.8 % for ciprofloxacin. Triple resistance to the evaluated agents was uncommon and was detected in 1 % of the untreated children, 3.5 % of the untreated adults and 13.6 % of the treated adults. Five H. pylori strains were resistant to amoxicillin, metronidazole and clarithromycin, two of them exhibiting quadruple resistance. Resistance to four of the five antibacterials tested was found in 0.7 % of the untreated and 1.8 % of the treated adults. The overall level of multidrug resistance in the treated adults (15.4 %) was higher than that in the untreated adults (4.2 %, P50.0001) and the untreated children (1 %, P50.0001). The presence of multidrug H. pylori resistance in Bulgaria could be associated with many factors, among them the slightly increasing national use of macrolides, lincosamides and streptogramins and of quinolones since 2000, the significant increase in primary H. pylori clarithromycin resistance, the high tetracycline use between 1994 and 1999, and, in individual cases, the use of azithromycin-based regimens or reuse of nitroimidazoles. In conclusion, for the first time in a European country during the last 5 years, H. pylori strains harbouring a worrying quadruple antibacterial resistance were found in treated as well as in untreated patients. H. pylori susceptibility patterns have a tendency to become unpredictable and should be monitored constantly at both national and global levels.

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“…The prevalence of H. pylori strains with secondary resistance to clarithromycin was much higher than strains with primary resistance in the same population. However, few studies focused on this tough problem in children, and the rates of secondary clarithromycin resistance varied from 14.2% up to 78% .…”

Section: Prevalence Of Clarithromycin‐resistant Helicobacter Pylori Imentioning

confidence: 99%

Detection of Clarithromycin‐Resistant Helicobacter pylori by Stool PCR in Children: A Comprehensive Review of Literature

Xiong

Wang

et al. 2012

Helicobacter

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High level of resistance to metronidazole and clarithromycin inHelicobacter pylori isolated from pediatric patients in Poland (1997–2001)

Cited by 8 publications

References 15 publications

Antibacterial resistance and the success of tailored triple therapy in Helicobacter pylori strains isolated from Slovenian children

Antibacterial resistance and the success of tailored triple therapy in Helicobacter pylori strains isolated from Slovenian children

Prevalence of multidrug-resistant Helicobacter pylori in Bulgaria

Detection of Clarithromycin‐Resistant Helicobacter pylori by Stool PCR in Children: A Comprehensive Review of Literature

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