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Synopsis Collagen being the main structural protein of the skin, the influence of a face cream containing this molecule was studied in the dermis using differential scanning calorimetry. This method, using samples of rat dermis, gives curves from which the denaturation temperature and enthalpy change of the collagen fibre network can be followed. The present study was made using two groups of rats which were treated by the cream (or placebo) during 4 months (5 days a week), and were aged 5 and 9 months at.