Influence of collagen denaturation on the chemorheological properties of skin, assessed by differential scanning calorimetry and hydrothermal isometric tension measurement

Temperature Dependence of Thermal Damage to the Sclera: Exploring the Heat Tolerance of the Sclera for Transscleral Thermotherapy

“…Thermal damage to corneal collagen developed at 60±658C (Shaw and Gasset, 1994;Spo Èrl et al, 1996); heating at 63±658C for 3 min caused diffuse disintegration and an increase in the diameter of corneal collagen ®bers (Timberlake et al, 1993). Heat-induced changes at 658C were also observed in collagen I of tendons (Vangsness et al, 1997), joint capsule (Hayashi et al, 1997a), and skin (Le Lous et al, 1982;Zweig et al, 1990), and at 708C in arteries (Gorisch and Boergen, 1982;Agah et al, 1994).…”

Nonablative skin remodeling: Selective dermal heating with a mid-infrared laser and contact cooling combination

“…Temperatures greater than 60-65°C have been shown to shrink collagen along its long axis for exposures of 90 seconds or greater [10][11][12][13]. For millisecond time exposures in laser skin remodeling, the threshold temperatures for denaturation are probably higher, likely to be in the range of 90-120°C [14,15].…”

Comparison of Normal and in vitro Aging by Non-Enzymatic Glycation as Verified by Differential Scanning Calorimetry

“…In this technique, the specific enthalpy change is due to denaturation of RTT collagen molecules. Collagen denaturation is an endothermic reaction [2] at a slow rate under equilibrium conditions. It can be studied by DSC, although under realistic heating rates (1-10 K/min) equilibrium is not attained [20].…”

“…Among these, decreased proteolytic digestibility [1], increased heat denaturation time [2], and accumulation of fluorescent materials [3] are the most prominent ones. These alterations are mainly found in collagen-rich tissues and are thought to result from the formation of age-related cross-links.…”