Oral diseases play a serious challenge to public health around the world. When left untreated, both the mouth and also the remaining the body would be adversely affected by oral diseases. Different treatment modalities are available for various dental diseases, but the most downside of those modern drug treatments are the frequent side effects related to their use. This has contributed to renewing interest in the development of novel plant-derived anti-infective natural compounds. Curcumin is an anti-inflammatory agent that occurs naturally, with different biological and medicinal properties. It has proven anti-inflammatory, antioxidant, antimicrobial, hepato-protective, immuno-stimulant, antiseptic, and anti-mutagenic properties. Due to these properties, it is especially useful in dentistry for the treatment of periodontal diseases and oral cancers. Turmeric can also be utilized in alternative treatments as a pit and fissure sealant, mouthwash and subgingival irrigant. Its gel form can even be used as a local drug delivery system. It is evaluated with a view to mitigate the human diseases, particularly in cancer and its potential to reduce cancer risk. Curcumin has only negligible side effects such as diarrhoea, diarrhoea, allergic skin reaction, gastric pain. The objective of this article is to review the efficacy and therapeutic properties of curcumin in maintaining oral health.

Aim: UHPLC method was developed and validated for the determination of Paracetamol, Aceclofenac and Chlorzoxazone in pharmaceutical dosage form.Methods: Separation was performed in Agilent technologies 1220 infinity LC system equipped with open lab CDS Chemstation software using Eclipse plus C18 (50 × 4.6 mm id, 1.8 µm) column with mobile phase containing 0.05% orthophosphoric acid, adjusted to pH 6.0 with triethylamine and acetonitrile in the ratio of 70:30 v/v with a flow rate of 0.5 mL/min and detection wavelength 270 nm. Results:The method was found to be linear in the concentration range of 161.59-484.77 µg/mL for paracetamol, 49.69-149.09 µg/mL for aceclofenac and 124.81-374.43 µg/mL for chlorzoxazone with correlation coefficient of 0.999 for all the three drugs respectively. The %RSD of 0.57, 0.45 and 0.60 for intra-day and 0.96, 0.88 and 0.84 for inter-day precision, respectively for of Paracetamol, Aceclofenac and Chlorzoxazone suggest the precision of the method as all these values are less than 2%. The method has shown good, consistent recoveries for of Paracetamol (99.90-99.95%), Aceclofenac (99.83-99.92%) and Chlorzoxazone (99.39-99.59%) which are close to 100%. Conclusion:The method was found to be accurate, precise, specific, robust and linear for the determination of Paracetamol, Aceclofenac and Chlorzoxazone in pharmaceutical dosage form.

An allergic response is the hypersensitive immune response to a substance which is normally harmless or would not cause an immune response in everyone. An allergic response can cause several symptoms such as itching, inflammation and tissue injury. The manifestation of allergies is recognized in the form of urticaria, swelling, burning, pain, and dryness of the mucosa, stomatitis. radioallergosorbent test (RAST) which is the radioallergosorbent test used for the confirmation of allergic reaction in the body. This test specifically deals with the IgE antibodies which are responsible for the allergic reactions on the body. It is very essential to crosscheck the exact history related to allergy. Individual sensitivity and population sensitivity, both are equally responsible for skin allergy are the factors which are to be considered. Skin tests become negative under conditions of severe allergic reactions which is determined by graded therapy by freedom from contact and using epinephrine administration. RAST test is a two-stage procedure. RAST-test is performed according to the guidelines of European Committee on Antimicrobial Susceptibility (EUCAST). The reliability of the test is high compared to other skin tests. Specificity based on two radioallergosorbent tests is high as 90% for inhaled allergens. It shows excellent reproducibility across a full measuring range with the help of the calibration curve. The RAST test is considered to be extremely sensitive. It shows high specificity which binds to allergen-specific IgE. This article mainly deals with the RAST procedure, advantages and disadvantages of the test.

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