The reaction of 2-alkoxypropenals with organylthiols in the presence of small amounts of a base afforded 3-organylsulfanyl-2-alkoxypropanals. The regiochemistry follows the 1,4-addition pattern and contrasts the orientation of the Markovnikov addition, which takes place in the absence of a base. Microwave irradiation accelerates the 1,4-addition reaction.
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