The reaction of 2-alkoxypropenals with organylthiols in the presence of small amounts of a base afforded 3-organylsulfanyl-2-alkoxypropanals. The regiochemistry follows the 1,4-addition pattern and contrasts the orientation of the Markovnikov addition, which takes place in the absence of a base. Microwave irradiation accelerates the 1,4-addition reaction.
ketone derivativesketone derivatives (acyclic compounds) P 0220
-084Kinetic and Thermodynamic Control in the Synthesis of Methylglyoxal Thioacetals from 2-Ethoxypropenal.-The addition of thiols (II) and (VIII) to 2-ethoxypropenal (I) and the isomerization reactions of the products is studied by NMR spectroscopy. -(KEIKO, NATALIYA A.; FUNTIKOVA, EVGENIYA A.; STEPANOVA, LYUDMILA G.; CHUVASHEV, YURII A.; LARINA, LYUDMILA I.; VORONKOV, MIKHAIL G.; Mendeleev
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