The aim of this study was to find a safe, effective sterilization method that does not destroy the bone-inductive capacity of demineralized bone implants. Five sterilizing agents were tested in rats. Implants procured and processed under sterile conditions served as controls. New bone formation was evaluated by determining dry weight, calcium content, and Sr-85 incorporation of the induced ossicles. Glutaraldehyde solution, formaldehyde gas, and ethylene oxide destroyed almost all the bone-inductive capacity. Irradiation by 2.5 Mrads Co-60 resulted in a loss of about half of the inductive capacity. Merthiolate (0.18 per cent) was the only sterilizing agent that did not reduce the bone-inductive capacity of the demineralized implants. Because merthiolate is not sporicidal, gamma irradiation appears to be the most appropriate sterilizing agent for demineralized bone in clinical use.
The kinetics of the thermal decomposition of stoichiometric hydroxylapatite (HA) has been studied up to 1500°C for the purpose of determining the maximum admissible combinations of temperature and time for sintering HA. The influence of the sintering temperature on shrinkage, density and grain growth is then investigated in the temperature range from 1000 to 1450 °C. Nearly theoretical density was achieved above 1300 °C. A maximum fracture toughness is obtained for the samples sintered at 1300°C whereas hardness increases up to a sintering temperature of 1400 °C. These results are discussed in terms of the roles of porosity and grain size.
The unadjusted rate of incidental DT during decompression for LSS was homogeneous across the participating centres and was associated with age, BMI, previous surgery at the same spinal level, minimally/less invasive surgery, and laminectomy. Non-repair of DTs had no negative association with treatment outcome; however, the unrepaired DTs may have been those that were smaller in size.
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