Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body

Banse, Xavier; Devogelaer, Jean‐Pierre; Munting, Everard; Delloye, Christian; Cornu, Olivier; Grynpas, Marc D.

doi:10.1016/s8756-3282(01)00425-2

Cited by 111 publications

(78 citation statements)

References 29 publications

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“…Rarely are data considered for single vertebral levels [12], yet even in these circumstances the aBMD and BMC data are calculated based on the whole vertebral body area. This approach precludes characterisation of any heterogeneity in the distribution of BMC within the vertebral body, despite a large volume of literature confirming that BMC is not homogenously distributed throughout the vertebral centrum [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] and that the distribution of bone mass relates to vertebral strength and fracture mechanics [24,28,29]. We developed a protocol to measure aBMD within vertebral subregions using lateral-projection DXA [15,16,30], and applied this protocol to a population with osteoporosis and without vertebral fractures.…”

Section: Introductionmentioning

confidence: 99%

Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: validation with peripheral quantitative computed tomography

et al. 2011

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Although a strong relationship exists between areal bone mineral density (aBMD) derived from dual energy X-ray absorptiometry (DXA) and bone strength, the predictive validity of aBMD for osteoporotic vertebral fractures remains suboptimal. The diagnostic sensitivity of DXA may be improved by assessing aBMD within vertebral subregions, rather than relying on an estimate derived from the total area of the vertebra. The objective of this study was to validate a method of measuring subregional vertebral aBMD in vitro using lateral-projection DXA against subregional volumetric BMD (vBMD) measured with peripheral quantitative computed tomography (pQCT). A mixed set 49 lumbar and thoracic vertebrae from 25 donors were scanned using lateralprojection DXA and pQCT. ABMD and apparent vBMD were measured in 7 vertebral regions (1 total area and 6 subregions) from the lateral DXA scan. VBMD was calculated in anatomically equivalent regions from pQCT scan data, using a customised software program designed to increase efficiency of the analysis process. Significant differences in densitometric parameters between subregions were observed by DXA and pQCT (p<0.01). Subregional vBMD derived from pQCT was explained by a significant proportion of the variance in DXA-derived aBMD (R 2 =0.51-0.67, p<0.05) and apparent vBMD (R 2 =0.64-0.75, p<0.05). These results confirm the validity of measuring aBMD in vertebral subregions using lateral-projection DXA. The clinical significance should now be explored. Subregional vertebral bone mineral density4

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Section: Introductionmentioning

confidence: 99%

Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: validation with peripheral quantitative computed tomography

et al. 2011

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“…Leakage of cement into tended to move to the central portion of the disc. In addition, a prior study on the systematic density and structural patterns inside the vertebral body proposes that the weak part was in the upper half of the body 22 . Our study supported this theory as in our study most leakages occurred at this location.…”

Section: Discussionmentioning

confidence: 99%

Is Intervertebral Cement Leakage a Risk Factor for New Adjacent Vertebral Collapse?

et al. 2014

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This retrospective study evaluated the relationship between intervertebral cement leakage and new adjacent vertebral fracture and describes the different characteristics of cement leakage. Increased risk of new adjacent vertebral fracture (NF) has been reported to be a complication of cement leakage in vertebroplasty. In our observation, an incidental intervertebral cement leakage may occur during vertebroplasty but is commonly asymptomatic. The study focused on osteoporotic collapse patients who had percutaneous vertebroplasty (PV) between 2005 and 2007. We divided patients into leakage and non-leakage groups and compared the incidence of NF. Leakage characteristics were divided into three types: Type I intervertebral-extradiscal leakage, Type II intradiscal leakage and Type III combined leakage. Visual analog scale for pain and the Karnofsky Performance Status at 24 h, three months, six months and one year were compared between groups and types of leakages. Among 148 PVs (102 patients) there were 30 leakages (20.27%) and 21(14.19%) NFs. The incidence of NF did not significantly differ between leakage and non-leakage groups (P<0.05). Type II was the most common type of leakage (15/30). Reduction of average pain and improvement of Karnofsky Performance Status score did not differ between groups (P<0.05). Type II had decreased pain score < type I and III at 24 h (P < 0.01), three months and six months (P < 0.1) but not at one year (P<0.10). Type II also had decreased pain score < non-leakage group only at 24 h (P<0.05). Intervertebral cement leakage is not an increased risk for NF, influenced outcomes of pain relief or improvement of physical function. Intradiscal leakage (Type II) is the most common characteristic of cement leakage and probably related to delayed pain relief.

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“…On the other hand, the vertebral bodies of patients with arthrosis may show other additional changes. For example, the posterior half of the vertebral bodies usually has a higher trabecular density than the anterior 29 , which facilitates the appearance of vertebral fractures in those patients with spondyloarthrosis. In turn, these changes may have a relationship with the degeneration of the intervertebral disc.…”

Section: Spondyloarthrosis and Vertebral Fracturementioning

confidence: 99%

Osteoporosis y artrosis: ¿dos enfermedades mutuamente excluyentes o dos entidades relacionadas?

Rodrigo¹,

Martínez

Hernández

2013

Rev Osteoporos Metab Miner

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SummaryThe possible association between osteoporosis and osteoarthritis represents an ongoing matter of debate. It was considered, for decades, that both diseases were mutually exclusive due to the anthropometric characteristics and the difference in bone mass that patients with osteoporosis and osteoarthritis often present. However, in recent years, it was pointed out that both processes can coexist, and even that they may have a direct relationship. In this paper we review some aspects of the association between both diseases from a temporal perspective.

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Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body

Cited by 111 publications

References 29 publications

Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: validation with peripheral quantitative computed tomography

Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: validation with peripheral quantitative computed tomography

Is Intervertebral Cement Leakage a Risk Factor for New Adjacent Vertebral Collapse?

Osteoporosis y artrosis: ¿dos enfermedades mutuamente excluyentes o dos entidades relacionadas?

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