The influence of high sintering temperatures on the mechanical properties of hydroxylapatite

Landuyt, P. Van; Li, F.; Keustermans, J. P.; Streydio, Jean-Marie; Delannay, Francis; Munting, Everard

doi:10.1007/bf00121239

Cited by 148 publications

(93 citation statements)

References 9 publications

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“…To fabricate PLGA/HA composite material, we used nano-sized HA particles. Highly crystalline HA degrades over a long period in vivo, and incompletely degraded residual HA may hinder or retard complete bone healing 25) . Therefore, we reduced the total amount of HA and simultaneously enhanced HA exposure to the scaffold surface by using nano-sized HA particles instead of micro-sized HA particles 19) .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Osteogenic Potential Between Apatite-Coated Poly(Lactide-Co-Glycolide)/Hydroxyapatite Particulates and Bio-Oss

Kim

2008

Dent. Mater. J.

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Previously, we developed a poly(lactide-co-glycolide)/nano-hydroxyapatite (PLGA/HA) composite that overcame the limitations of conventional ceramic bone substitutes. This was achieved by introducing a bone-like apatite layer on the composite to further enhance its osteogenic potential. In this study, we compared the osteogenic potential of the apatitecoated PLGA/HA particulates to that of Bio-Oss ® , a deproteinized bovine bone material. A mixture of fibrin gel and either apatite-coated PLGA/HA particulates or Bio-Oss ® was implanted into critical-size rat calvarial defects. As a control, fibrin gel was implanted alone into the defects. At eight weeks after treatment, histological examination showed new bone formation around the grafting materials, and bone formation was similar between the two groups. In the control group, bone was not regenerated and the defects were filled with fibrous tissues. This study showed that a synthetic bone graft material, apatite-coated PLGA/HA particulates, had a comparable bone regeneration potential to the bovine-derived bone graft material, Bio-Oss ® .

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Section: Discussionmentioning

confidence: 99%

Comparison of Osteogenic Potential Between Apatite-Coated Poly(Lactide-Co-Glycolide)/Hydroxyapatite Particulates and Bio-Oss

Kim

2008

Dent. Mater. J.

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“…Fluorescence was measured in a spectrofluorophotometer (Spectramax M2, Molecular Devices, Sunnyvale, USA) at excitation and emission wavelengths 480 nm and 520 nm, respectively. In some studies, DNA contents of 2.5×10 5 , 5×10 5 , and 1×10 6 hMSC were determined. Using this standard curve, we estimated the number of cells in the cell scaffold complexes.…”

Section: Dna and Calculation Of Cell Numbermentioning

confidence: 99%

“…However, their clinical applications have been limited because of their brittleness, difficulty of shaping 4) , and a slow degradation rate in the case of hydroxyapatite (HAP) 5) . Increasing interest has currently been focused on polymer/ceramic composite materials as bone substitutes [6][7][8][9][10][11] , because these materials may have advantages over polymer and ceramic scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Seeding of mesenchymal stem cells into inner part of interconnected porous biodegradable scaffold by a new method with a filter paper

et al. 2015

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An appropriate physical support provided by scaffolds creates a supportive environment that directs proliferation and differentiation of stem cells. However, it is difficult to homogenously inoculate stem cells into the inner part of scaffolds at high cell densities. In this study, mesenchymal stem cells were seeded into a hydroxyapatite/poly (D, L-lactic-co-glycolic acid) (HAP/PLGA) scaffold that had enough mechanical strength and porous 3-D structure. With an aid of a filter paper placed under the bottom of a HAP/PLGA block, the cells suspended in a culture medium flowed from the top to the bottom through interconnected pores in the scaffold, and distributed almost homogenously, as compared to cell distribution near the surface of the block by the conventional method using centrifugation or reduced pressure. This simple method with a filter paper may be useful in preparation of cell-scaffold complexes for tissue engineering.

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“…Fourthly, a chemical decomposition of all acidic orthophosphates and their transformation into other phosphates (e.g., 2HPO 4 2-→ P 2 O 7 4-+ H 2 O↑) takes place. Besides, sintering causes toughening [247], densification [248,249], partial dehydroxylation (in the case of HA) [249], as well as it increases the mechanical strength [250,251]. The latter events are due to presence of air and other gases filling gaps among the particles of unsintered powders.…”

Section: Sintering and Firingmentioning

confidence: 99%

Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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The influence of high sintering temperatures on the mechanical properties of hydroxylapatite

Cited by 148 publications

References 9 publications

Comparison of Osteogenic Potential Between Apatite-Coated Poly(Lactide-Co-Glycolide)/Hydroxyapatite Particulates and Bio-Oss

Comparison of Osteogenic Potential Between Apatite-Coated Poly(Lactide-Co-Glycolide)/Hydroxyapatite Particulates and Bio-Oss

Seeding of mesenchymal stem cells into inner part of interconnected porous biodegradable scaffold by a new method with a filter paper

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