We propose a new shape-based segmentation approach using the statistical shape prior and level sets method. The segmentation depends on the image information and shape prior. Training shapes are grouped to form a probabilistic model. The shape model is embedded into the image domain taking in consideration the evolution of a contour represented by a level set function. The evolution of the front gathers information from the image intensities and shape prior. The segmentation approach is applied in segmenting the vertebral bodies in CT images. Our results shows that the technique is accurate and robust compared with the other alternative in the literature.Index Terms-Simultaneous segmentation and registration, vertebral body (VB).

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