The quest for new antibiotic substances produced by microorganisms has stimulated investigations on comparatively simple synthetic compounds, particularly those having structural features common to several of the natural antibiotics. Geiger and Conn2 have called attention to the structural feature, -CH=C-C=0 common to I both penicillic acid and clavacin and have postulated that the antibacterial activity of both compounds is very likely closely associated with this grouping. The fact that both clavacin, penicillic
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