Yacon tubers contain various bioactive including flavonoids and phenolic compounds, having antioksidant properties. The aim of the study was to obtain the effect of using natural inhibitors on the antioxidant activity of yacon tubers syrup. Phytochemical tests are used in the determination of flavonoids, phenolic content and antioxidant activity. Total content of phenol and flavonoid were measured by spectrophotometry, while the antioxidant activity was measured by DPPH method. The results showed that the use of natural inhibitors affects the antioxidant activity of yacon tuber syrup. The content of flavonoids and phenolic compounds in yacon syrup using natural inhibitors were 148.093±3.973 and 1244.595±67.672 ppm, significantly different from yacon syrup without inhibitors 100.923±9.277 and 978.912±54.223ppm. Antioxidant activity of syrup with natural inhibitors were 52.888% and IC50: 6.383, while yacon syrup without inhibitors were 24.388% and IC50: 11.180.
Moringa oleifera tergolong mudah dijumpai di Indonesia dan mengandung senyawa quercetin yang termasuk dalam jenis flavonoid, dimana senyawa ini berperan sebagai agen hipoglikemik. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak Moringa oleifera terhadap kadar glukosa dan histopatologi pankreas mencit hiperglikemia. Metode yang digunakan pada penelitian ini yaitu ekstraksi daun Moringa oleifera dengan konsentrasi 42 mg/kgBB, 70 mg/kgBB, dan 98 mg/kgBB, lalu penginduksian aloksan secara intraperitoneal, pengaplikasian ekstrak Moringa oleifera, pengambilan organ pankreas dan pembuatan histologi organ pankreas. Hasil penelitian menunjukkan bahwa Pemberian ekstrak Moringa oleifera berpengaruh pada penurunan kadar glukosa dan penambahan diameter pulau Langerhans pankreas mencit diabetes. Konsentrasi ekstrak yang paling berpengaruh adalah 98 mg/kgBB. Maka dapat diambil simpulan bahwa ekstrak Moringa oleifera pada konsentrasi berpotensi sebagai antihiperglikemia.
Ageratum conyzoides L. leaf has the main compound of flavonoids and alkaloids that contribute to accelerate the healing process of diabetic ulcers with Staphylococcus aureus infection that can affect the quality of life of patients. This study aims to test the leaves of Ageratum conyzoides L. on the recovery of diabetic ulcers of mice infected with Staphylococcus aureus. The method used is the extraction of Ageratum conyzoides L leaves as the material of spray 15%, induction of diabetic compound (Alloxan monohydrate), length wound (1cm) and bacterial infections, and spray application with 1 times daily frequency, 2 times daily, 3 times a day for 9 days. The results showed that the lenght of wounds in group A, B, C, D, and E were 0,5; 0,8; 0,4; 0,2; 0,0. The administration of Ageratum conyzoides L. spray which has active flavonoide substances, alkaloid substance, and saponin substances has an effect on decreased length of diabetic wounds and restoration of dermis tissue structure (increases epithelial cells proliferation, initiates fibroblast cells, and stimulates type 1 collagen). Spray treatment 3 times a day (group E) was more influential than the other treatments, which experienced wound closure in 9 days. Thus, Ageratum conyzoides L. leaf spray is potential for therapy of diabetic ulcers infected with Staphylococcus aureus. ABSTRAKDaun Ageratum conyzoides L. memiliki senyawa utama flavonoid dan alkaloid yang berkontribusi dalam mempercepat proses penyembuhan ulkus diabetikum dengan infeksi bakteri Staphylococcus aureus yang dapat mempengaruhi kualitas hidup penderita. Penelitian ini bertujuan untuk menguji potensi daun Ageratum conyzoides L. terhadap pemulihan luka diabetik mencit terinfeksi bakteri Staphylococcus aureus. Metode yang digunakan yaitu dengan ekstraksi daun Ageratum conyzoides L. untuk pembuatan spray 15%, induksi senyawa diabetik (Alloxan monohydrate), pembuatan panjang luka (1cm) dan infeksi bakteri, serta pengaplikasian spray dengan frekuensi pemberian 1 kali sehari, 2 kali sehari, 3 kali sehari selama 9 hari. Hasil penelitian menunjukkan panjang luka pada kelompok A, B, C, D, dan E berturut-turut adalah 0,5; 0,8; 0,4; 0,2; 0,0. Pemberian spray Ageratum conyzoides L. yang memiliki zat aktif flavonid, alkaloid dan saponin berpengaruh pada berkurangnya panjang luka diabetik dan pemulihan struktur jaringan dermis (meningkatkan proliferasi sel epitel, menginisiasi sel fibroblas, dan menstimulasi kolagen tipe 1). Perlakuan spray 3 kali sehari (kelompok E) lebih berpengaruh dibandingkan dengan perlakuan yang lain, yaitu mengalami penutupan luka dalam 9 hari. Dengan demikian, spray daun Ageratum conyzoides L. berpotensi untuk terapi ulkus diabetikum yang terinfeksi Staphylococcus aureus.
Cancer is estimated to be the second leading cause of death globally in 2018. The background of the study was the prevalence of cancer in Indonesia in 2018 reaching 775.120 people. Treatments such as surgery, chemotherapy, radiotherapy, immunotherapy, and hormone therapy have negative side effects. Herbal medicine is an alternative treatment with lower side effects that can reduce the side effects of existing treatments. The aim of this study was to identify the results of GC-MS active compounds from ethanol extract of zodia leaves which have the potential as anticancer. The method of this research was observational research through scientific literature. GC-MS results showed 22 active compounds contained in ethanol extract of zodia leaves. Based on the literature searching, there are 17 active compounds that have potential to be anticancer. Menthofuran; evodone; Bicyclopentene; Delta-Selinene; 3,5,7-Octatrien-2-Ol, 2,6-Dimethyl; Aromadendrene oxide 2; Alpha-bisabolol; 2,4-Dimethyl-2,4-Heptadienal; Phytol; Squalene; Beta-Tocopherol; D-alpha-Tocopherol; Stigmasta-5,23-dien-3.beta.-ol; (23S)-ethylcholest-5-en-3.beta.ol; 24,25-Dihydrolanosterol; Lanosterol; and Obtusifoliol. The compounds are targeted in breast, lung, and ovarian cancer.
The research was conducted on May to July 2019, in Pamekasan, Madura, East Java, Indonesia. The aim of this study is to know the nutritional content of Solen sp. (Lorjuk) the shellfish which live and consumed by local community in Madura. This is a descriptive quantitative research. Parameters that used in determining the nutritional quality of the shellfish were water content, ash content, protein, fat and carbohydrates using gravimetry methods. The results of laboratory analysis showed that the ash content and carbohydrates were he highest nutritional content of lorjuk/ razor clams (Solen sp.). Nutritional content of Solen sp. (Lorjuk) were ater content of 0.69%; ash content of 25.40%; protein of 2.63%; fat of 1.06% and carbohydrates of 70.22%. Based on morphometric analysis, the results obtained, length, width, thickness and intact weight of Solen sp. that breed in Pamekasan Madura were 0.56 cm; 0.79 cm; 0.74 cm; and 2.19 gram.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.