The aim of this research was to determine the sun protection factor (SPF) of sunscreens emulsions containing chemical and physical sunscreens by ultraviolet spectrophotometry. Ten different commercially available samples of sunscreen emulsions of various manufactures were evaluated. The SPF labeled values were in the range of 8 to 30. The SPF values of the 30% of the analyzed samples are in close agreement with the labeled SPF, 30% presented SPF values above the labeled amount and 40% presented SPF values under the labeled amount. The proposed spectrophotometric method is simple and rapid for the in vitro determination of SPF values of sunscreens emulsions.

Dual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis–encapsulation processes.

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The separation and quantitative determination of atenolol isomers by chiral high-performance liquid chromatography (HPLC) are described. Atenolol isomers were separated using a Chiralcel OD column (250 x 4.6 mm, 10 microns); the mobile phase was hexane-ethanol-diethylamine (75:25:0.1 v/v/v); ultraviolet detection was at 276 nm; and flow rate was 0.7 ml/min. The coefficient of variation and average recovery of (R)-isomer were 0.60% and 100.37%, respectively, for sample A and 0.69% and 100.63%, respectively, for sample B. The coefficient of variation and average recovery of (S)-isomer were 0.59% and 100.33%, respectively, for sample A and 0.63% and 99.78%, respectively, for sample B.

This work reports an application of chiral high-performance liquid chromatography (HPLC) in the separation and quantitative determination of propranolol isomers in tablets. The isomers were separated using a Chiralcel OD column (250 x 4.6 mm, 10 microm) with a mobile phase of hexane:ethanol (75:25 v/v) at a flow rate of 0.7 ml/min and ultraviolet detection at 280nm. The coefficient of variation and average recovery of (R)-isomer for samples A, B, C, and D were 0.72% and 100.30%, 0.67% and 99.40%, 0.62% and 99.76%, and 0.70% and 99.68%, respectively. The coefficient of variation and average recovery of (S)-isomer for samples A, B, C, and D were 0.74% and 99.62%, 0.64% and 100.27%, 0.71% and 99.99%, and 0.70% and 99.72%, respectively.