Estrogen binding sites were identified on plasma membranes from biopsy materials (N = 16) of normal human larynx; such binding was found to be specific. In tissue from 22 cases of laryngeal papilloma, membrane binding of 17-beta-estradiol was also specific. Although such binding occurred for papilloma membranes at a comparable affinity, it was clear that all membranes from the papillomatous tissue possessed a 148% greater estrogen binding capacity; there were at least 17 times more estrogen binding sites for each mg of receptor protein on papilloma membrane than for normal laryngeal epithelium. These findings suggest a possible receptor marker for the detection and/or prediction of recurrence of laryngeal papilloma.
Rats exposed to marijuana smoke injected into a chamber immediately after passive avoidance training, showed a significant failure to perform the conditioned avoidance response 24 hr. later. A delivered dose of marijuana resulted in appreciable concentrations of its major behaviorally active metabolite, Δ9-tetrahydrocannabinol (Δ9-THC) in the absence of gross signs of intoxication, 24 hr. later. The greatest regional brain concentration of Δ9-THC occurred in the hippocampus, a region usually associated with memory trace processing and retention. The present study demonstrates that (1) marijuana intoxication can produce a retrograde amnesia in rats and (2) the amnesic effect is likely to depend upon Δ9-THC accumulation in the hippocampus and is probably not dependent upon the post-training intoxication state.
The topical application of sodium fluoride to abraded rat skin produced several morphological and biochemical effects. Related to the degranulation of dermal mast cells, skin histamine concentration was increased, fluorides were absorbed into the skin, and deposited mainly kin mitochondria. Dermal histamine binding was decreased for both H1 and H2 receptors with reduced binding sites, but epidermal adenyl cyclase was activated by fluorides. The response of the rat skin to fluorides involves a sequence of changes by which the potentiation of an inflammatory response also involves alterations in specific histamine receptors and a histamine-specific adenyl cyclase system.
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