Histaminergic mediation of the response of rat skin to topical fluorides

Abstract

The topical application of sodium fluoride to abraded rat skin produced several morphological and biochemical effects. Related to the degranulation of dermal mast cells, skin histamine concentration was increased, fluorides were absorbed into the skin, and deposited mainly kin mitochondria. Dermal histamine binding was decreased for both H1 and H2 receptors with reduced binding sites, but epidermal adenyl cyclase was activated by fluorides. The response of the rat skin to fluorides involves a sequence of changes by which the potentiation of an inflammatory response also involves alterations in specific histamine receptors and a histamine-specific adenyl cyclase system.

Effects of Fluoride Exposure on Primary Human Melanocytes from Dark and Light Skin

“…Topical or system application of fluoride has been shown to induce cutaneous reactivity in animal models. For example, a fluoride-containing prophylaxis paste that was implanted subcutaneously in rats elicited cutaneous inflammatory reactions [27] and increased histamine levels when applied topically [28]. On the other hand, few studies have documented the in vitro effects of fluoride on keratinocytes, cells which constitute the skin barrier layer in the epidermis [29,30].…”