Estrogen binding sites on membranes from human laryngeal papilloma

Essman, Eric J.; Abramson, Allan L.

doi:10.1002/ijc.2910330107

Cited by 32 publications

(10 citation statements)

References 18 publications

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“…The dietary supplement indole‐3‐carbinol, which is found in high concentrations in cruciferous vegetables such as cabbage, cauliflower, and broccoli, has been evaluated for treating RRP. The rationale is that RRP lesions exhibit increased binding of estrogen, 88 and a study in immunocompromised mice showed that inhibition of estrogen metabolism using indole‐3‐carbinol reduced the formation of HPV‐induced papilloma tumors by nearly 75% 89 . In an open‐label, multicenter study in children with RRP, Rosen and Bryson 90 found that after 8 months or more of treatment, one third of patients had cessation of papilloma growth and did not require further surgery, one third had reduced papilloma growth rate, and one third had no evident response.…”

Section: Adjuvant Treatment Modalitiesmentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: A Review

2008

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Recurrent respiratory papillomatosis (RRP), which is caused by human papillomavirus types 6 and 11, is the most common benign neoplasm of the larynx among children and the second most frequent cause of childhood hoarseness. After changes in voice, stridor is the second most common symptom, first inspiratory and then biphasic. Less common presenting symptoms include chronic cough, recurrent pneumonia, failure to thrive, dyspnea, dysphagia, or acute respiratory distress, especially in infants with an upper respiratory tract infection. Differential diagnoses include asthma, croup, allergies, vocal nodules, or bronchitis. Reports estimate the incidence of RRP in the United States at 4.3 per 100,000 children and 1.8 per 100,000 adults. Infection in children has been associated with vertical transmission during vaginal delivery from an infected mother. Younger age at diagnosis is associated with more aggressive disease and the need for more frequent surgical procedures to decrease the airway burden. When surgical therapy is needed more frequently than four times in 12 months or there is evidence of RRP outside the larynx, adjuvant medical therapy should be considered. Adjuvant therapies that have been investigated include dietary supplements, control of extra-esophageal reflux disease, potent antiviral and chemotherapeutic agents, and photodynamic therapies; although several have shown promise, none to date has "cured" RRP, and some may have serious side effects. Because RRP, although histologically benign, is so difficult to control and can cause severe morbidity and death, better therapies are needed. The potential for a quadrivalent human papilloma vaccine is being explored to reduce the incidence of this disease.

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Section: Adjuvant Treatment Modalitiesmentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: A Review

2008

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“…Estrogen receptors have been identified in laryngeal epithelial tissue, and HPV infection increases estrogen receptor density within the epithelium. 75 In fact, increased levels of this hormone at puberty may account for the high remission rate of RRP during adolescence. Topical application of estrogen has been proposed because it can thicken the mucosa, 63,76 which may prevent recur-rence of laryngeal papillomas.…”

Section: Role Of Adjuvant Medical Therapy For Pediatric Recurrent Resmentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population

et al. 2004

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Statistical analysis of the relationships among epidemiological factors, HPV type, and clinical course revealed that patients with HPV-11 and patients younger than 3 years of age at RRP diagnosis are prone to develop more aggressive disease as represented by higher severity scores at endoscopic debridement, more frequent operative debridement procedures per year, a greater requirement for adjuvant therapy, and greater likelihood of tracheal disease with tracheotomy.

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“…Vocal folds have estrogen receptors and laryngeal papillomas have a much greater estrogen-binding capacity than normal tissue. 15 When laryngeal tissue infected with HPV11 was implanted into mice in an animal study, 100% of the mice in the control group developed tumors, but only 25% of the mice in the I3C-injected group developed tumors and a preventive effect was seen in 75% of the mice. 16 Rosen et al reported that 11 out of 33 patients with an average age of 48 years who took 200 mg of I3C twice a day for an average of 50 months were completely cured at long-term follow-up.…”

Section: Indole-3-carbinolmentioning

confidence: 99%