Treatment of Recurrent Respiratory Papillomatosis Using Laser and Available Adjuvant Therapies

Woo, Seung Hoon; Chung, Phil‐Sang; Lee, Sang Joon

doi:10.25289/ml.2020.9.2.126

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…RRP is still mainly based on surgical treatment, the most commonly used is microdebrider [15] , CO2 laser [16] or 532nm Potassium-Titanyl-Phosphate laser (KTP laser) [17][18][19][20][21][22][23][24] . However, surgery does not seem to completely prevent the recurrence of the disease, and the efficacy of a variety of existing adjuvant treatments is not clear, and some patients often require repeated surgery.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Liu,

He,

et al. 2023

Preprint

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Objectives: Part I analyzes the clinical characteristics of JO-RRP and AO-RRP. Part II explores the influencing factors of surgical intervals. Methods: Part I: Clinical features were analyzed in 168 RRP patients (59 JO-RRP and 109 AO-RRP) diagnosed and treated in our hospital. Part II: The correlation of interoperative time with onset age, gender, Derkay anatomical score or surgical methods were analyzed in JO-RRP patients. Results: The interoperative time between operations in the JO-RRP group was 116.3±75.9 days, and in the AO-RRP group was 169.1±141.7 days (p<0.05). In the JO-RRP group, the CO2 laser treatment interval (186.2±140.1 days) was significantly longer than that of the microdebrider group (124.7±114.5 days) (p=0.011). Conclusions: 1. JO-RRP patients had higher Derkay score, higher surgical frequency and shorter surgical interval. 2. The surgical intervals lengthened with age and shortened with higher Derkay scores. CO2 laser surgery has the longest interoperative time.

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Section: Introductionmentioning

confidence: 99%

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Liu,

He,

et al. 2023

Preprint

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“…Generally, Jo-onset RRP is the most common benign tumors in the larynx of children, shows a high recurrence rate and diffuse involvement in the respiratory tract, which are prone to recurrence, and require multiple surgeries, causing heavy psychological pressure and financial burden on families. On the contrary, Adult-onset RRP is more localized and appears more frequently as a solitary lesion [3]. Malignant transformation of adult-onset RRP to squamous cell carcinoma has been reported to occur in 3-7% of cases [4].…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Three Surgical Modalities for Recurrent Respiratory Papillomatosis

Liu

Wang

et al. 2022

Preprint

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Background：Recurrent respiratory papillomatosis (RRP) is recurring benign papillomatous lesions which still relies on repeated surgical treatment. However, there is no guidelines of surgical technique nowadays. Objectives: This retrospective cohort study aims to obtain a better understanding of RRP, and select the best surgical modality for RRP among microdebrider, CO2 laser and KTP laser. Study design: Retrospective cohort study. Methods: Medical records of 112 RRP patients treated at EYE&ENT Hospital of Fudan University from 2018 to 2021 were reviewed, with at least 6-month follow-up. Three treatment subgroups(microdebrider, CO2 laser and KTP laser) were analyzed within AO-RRP and JO-RRP populations respectively. Results: 112 patients (39 JO-RRP and 72 AO-RRP) and a total of 353 surgical procedures were included. Jo-RRP group had higher Derkay anatomical score(p<0.05), lower percentage of dysplasia and an earlier trend in recurrence(p<0.05) than Ao-RRP group. There were no significant differences among three surgical modalities on median treatment intervals(MTI) or survival curves(p>0.05), with the Jo-RRP MTI of the microdebrider(92.5[47.3~200]), CO2 laser(140[70~255]), KTP laser(90[62.3~221.3]), and Ao-RRP microdebrider(267.50[152.5,449.5]), CO2 laser(247.5[145.5,474.7]), KTP laser(107.5[68.3,330.5]). Conclusion and Significance: The Jo-RRP patients have more concomitant invasiveness, but less dysplasia than AO-RRP patients. Three surgical modalities appeare to be equally effective in management of Jo-RRP or AO-RRP. Key Words: Papillomatosis, surgery, treatment, recurrence, efficacy.

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Results of CO2 laser surgery in laryngeal papillomatosis

Solarz,

Mackiewicz–Nartowicz,

Sinkiewicz

et al. 2024

Oral Oncology

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Treatment of Recurrent Respiratory Papillomatosis Using Laser and Available Adjuvant Therapies

Cited by 5 publications

References 32 publications

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Comparative Efficacy of Three Surgical Modalities for Recurrent Respiratory Papillomatosis

Results of CO2 laser surgery in laryngeal papillomatosis

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