No abstract

Introduction Studies have shown that iron metabolism is affected by coronavirus disease 19 (COVID‐19), which has spread worldwide and has become a global health problem. Our study aimed to evaluate the relationship between COVID‐19 and serum erythropoietin (EPO), hepcidin, and haptoglobin (Hpt) levels with disease severity, and other biochemical values. Methods Fifty nine COVID‐19 patients hospitalized in the intensive care unit (ICU) and wards in our hospital between March and June 2020 and 19 healthy volunteers were included in the study. Participants were divided into mild, severe, and critical disease severity groups. Group mean values were analyzed with SPSS according to disease severity, mortality, and intubation status. Results Hemoglobin (Hb) levels were significantly lower in the critical patient group ( P < .0001) and deceased group ( P < .0001). The red blood cell distribution width‐coefficient of variation (RDW‐CV) and ferritin values were significantly higher in the intubated ( P = .001, P = .005) and deceased ( P = .014, P = .003) groups. Ferritin values were positively correlated with disease severity ( P < .0001). Serum iron levels were lower in the patient group compared with the reference range. ( P < .0001). It was found that the transferrin saturation (TfSat) was lower in the patient group compared with the control group ( P < .0001). It was found that the mean EPO of the deceased was lower than the control group and the survived patient group ( P = .035). Hepcidin levels were found to be significantly lower in the patient group ( P < .0001). Hpt values were found to be significantly lower in the intubated group ( P = .004) and the deceased group ( P = .042). Conclusion In our study, while serum iron and hepcidin levels decreased in patients diagnosed with COVID‐19, we found that EPO and Hpt levels were significantly lower in critical and deceased patient groups. Our study is the first study examining EPO and Hpt levels in patients diagnosed with COVID‐19.

No abstract

Background Hidradenitis suppurativa is a chronic inflammatory skin disease of terminal follicular acroinfundibulum. Objectives This study aimed to evaluate serum irisin, plasma glucose, insulin, and lipid levels in hidradenitis suppurativa, and elucidate possible associations with disease activity, inflammatory, or metabolic parameters. Methods This case-control study included 37 patients (M/F: 9/28) and 37 sex-, age- and body mass index -matched healthy controls (M/F: 11/26). Demographic data, Hurley stage of disease, fasting glucose, insulin, total cholesterol, high density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, C-reactive protein levels, erythrocyte sedimentation rate, hematologic parameters, and serum irisin were assessed. Results The hidradenitis suppurativa group had significantly higher waist circumference than controls ( p < 0.001). Insulin resistance, defined as a homeostatic model assessment for insulin resistance value greater than 2.5, was observed in 45.9% of patients and 8.1% of controls ( p = 0.003), whereas metabolic syndrome was observed in 32.4% of patients and 5.4% of controls ( p < 0.001). Furthermore, plasma triglycerids, glucose, and insulin levels were significantly higher in the hidradenitis suppurativa ( p = 0.013, p = 0.001, and p = 0.004), respectively. Mean irisin level was insignificantly higher in the hidradenitis suppurativa group (37.4 ± 32.6) than in controls (26.2 ± 24.7, p = 0.217). Study limitation Physical activity and the exercise levels of participants were not documented. Conclusion This study indicates that hidradenitis suppurativa patients have higher serum irisin, fasting plasma glucose, insulin, and triglycerides levels than healthy controls. Thus, the authors suggest that hidradenitis suppurativa patients should be evaluated for insulin resistance and metabolic syndrome, and monitored accordingly.