Recurrent aphthous stomatitis: investigation of possible etiologic factors

Koybasi, Serap; Parlak, Hande; Serin, Erdinç; Yılmaz, Fatma; Serin, Didem

doi:10.1016/j.amjoto.2005.09.022

Cited by 98 publications

(98 citation statements)

References 19 publications

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“…Until further research determines the molecular basis of mIAS, it is thus biologically plausible to conceptualize a pathobiologic model of mIAS in relation to the multifactorial mechanistic basis and clinical profile of recurrent aphthous ulceration as defined in the literature (Table 2) 7, 9, 10, 30, 31, 32, 33, 34, 35, 36, 37. Possible risk factors for recurrent aphthous ulceration have classically included anxiety and stress, hormonal alteration, and/or nutritional deficiency.…”

Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

et al. 2016

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In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state‐of‐the‐science regarding mTOR inhibitor‐associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2–78%). As reported across multiple mTOR inhibitor clinical trials, grade 3/4 toxicity occurs in up to 9% of patients. Managing mTOR‐associated oral lesions with topical oral, intralesional, and/or systemic steroids can be beneficial, in contrast to the lack of evidence supporting steroid treatment of oral mucositis caused by high‐dose chemotherapy or radiation. However, steroid management is not uniformly efficacious in all patients receiving mTOR inhibitors. Furthermore, technology does not presently exist to permit clinicians to predict a priori which of their patients will develop these lesions. There thus remains a strategic need to define the pathobiology of mIAS, the molecular basis of pain, and risk prediction relative to development of the clinical lesion. This knowledge could lead to novel future interventions designed to more effectively prevent mIAS and improve pain management if clinically significant mIAS lesions develop.

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Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

et al. 2016

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“…Ülkemizde de Köybaşı ve ark. yaptıkları bir çalışmada aile öyküsü varlığını %54,2 olarak bulmuştur 22 . Bulgularımız literatürle benzerlik göstermektedir.…”

Section: Discussionunclassified

Sociodemographic and clinical characteristics of patients with recurrent aphthous stomatitis

Bahalı¹,

Köktürk²,

Güvenç³

2014

TURKDERM

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Background and Design:The purpose of this study was to obtain data that may provide an insight into the etiopathogenesis of recurrent aphtous stomatitis (RAS) by the way of analysing the sociodemographic and clinical characteristics of patients who had been diagnosed with RAS. Materials and Metods: The patients, who were diagnosed with RAS in the dermatology outpatient clinic, between May 2007 and May 2010, were evaluated retrospectively. The data including sociodemografic and clinical characteristics, and treatment options were recorded. Results: A hundred patients (68 women, 32 men) were included in this study. The average age was 40±13.6 years. RAS was more common in patients with middle-income and low education. The most common type of RAS was minor aphtous ulcers (88%). The lesions were most frequently seen on the lateral side of the tongue (34%) and cheek (34%). Sixty percent of patients had a positive family history. Some factors such as biting (12%), tooth brushing (18%), dental disease presence (82%), food (39%), menstruation (10.3%), stress (76%), iron deficiency (16.7%), vitamin B12 deficiency (22.4%), low serum ferritin levels (18%), and seasonal variability (32%) showed positive correlation with RAS. A negative correlation was found between RAS and smoking. Forty-nine percent of patients had used alternative therapies in addition to drug therapy. The most frequently used alternative method was consumption of sumac (26.5%). Conlucions: In contrast to the literature, our study found that RAS is started in the third decade of life and, approximately 50% of patients prefered alternative treatment methods, particularly sumac. Nowadays, discussions about the etiopathogenesis of RAS continue. In this study, we found that different sociodemographic and clinical factors may be associated with the etiopathogenesis of the disease. Our study will be followed by further studies using prospective design to identify the the etiopathogenesis of RAS. (Turkderm 2014; 48: 242-8)

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“…[2][3][4][5][6][7] The role and prevalence of HD such as iron, folic acid and vitamin B12 deficiencies in the aetiopathogenesis of RAS are not well known and many conflicting results have been reported in the literature. 4,5,[7][8][9][10] Wray et al 8,11 reported increased incidence of HD in RAS patients and suggested haematological screening in such patients. While many researchers supported this relationship, 5,9-13 conflicting studies exist as well.…”

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confidence: 99%

“…While many researchers supported this relationship, 5,9-13 conflicting studies exist as well. 4,14,15 Olson et al 14 pointed out that serum deficiencies do not play a significant role in the aetiology of RAS. Koybasi et al 4 reported a significant correlation between RAS and vitamin B12 deficiency, while there is no direct association between serum iron, ferritin and haemoglobin levels and RAS.…”

mentioning

confidence: 99%

The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

Koray¹,

Ofluoğlu²,

Erden³

et al. 2016

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Recurrent aphthous stomatitis: investigation of possible etiologic factors

Cited by 98 publications

References 19 publications

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

Sociodemographic and clinical characteristics of patients with recurrent aphthous stomatitis

The Prevalence of Recurrent Aphthous Stomatitis in Patients With Hematinic Deficiency

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