8Neuropsychological deficits, such as poor episodic memory, are consistent features of mild cognitive impairment and also that of early stage of 9 dementia. The aim of the present study was to detect cognitive dysfunction among patients with Alzheimer's disease or with mild cognitive 10 impairment (MCI), which refers to a transitional state between the cognition of normal aeging and mild dementia regarded as a high-risk condition 11 for the development of clinically probable Alzheimer's disease (AD). Computerized tests of memory, attention and executive functions were 12 studied in groups of AD subjects (n = 15) and MCI subjects (n = 25). On all measures, the performance of the AD group was significantly weaker 13 compared to healthy individuals or to the MCI group. The performance of both the AD and MCI patients in the Paired Associate Learning test was 14 significantly impaired, which may suggest that MCI patients are already in the early stages of the disease. 15
A 130&m pilot-version of the QoL instrument in schizophrenia (QLIS) was analysed in 203 schizophrenics. Items were selected according to psychometric properties and content. In a validation study the resulting questionnaire was completed by n=l36 schizophrenic patients along with the WHOQOL-Bref, SWN-K and the German Version of the LQLR and by n=49 in a test-retest design. Reliability coefficients for the 10 subscales were satisfactory to good (median of retest-coefficients: 1=.80, median of internal consistencies: a =.75). Validity coefficients show that QLIS-scales differ empirically from present QoL instruments. QLIS, therefore, offers an opportunity for specific, comprehensive and reliable self-reported evaluation of QoL in schizophrenia.
decreased rCBF in superior frontal gyrus, right mesial (posterior hippocampus) and lateral temporal regions. Classic rCBF abnormalities seen in depressed patients appear to resolve following 10 weeks of VNS. Conclusion: These early data suggest that response to VNS therapy is associated with normalization of resting rCBF patterns.
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