Cognitive dysfunctions in prepsychosis

Abstract

A 130&m pilot-version of the QoL instrument in schizophrenia (QLIS) was analysed in 203 schizophrenics. Items were selected according to psychometric properties and content. In a validation study the resulting questionnaire was completed by n=l36 schizophrenic patients along with the WHOQOL-Bref, SWN-K and the German Version of the LQLR and by n=49 in a test-retest design. Reliability coefficients for the 10 subscales were satisfactory to good (median of retest-coefficients: 1=.80, median of internal consistencies: a =.75). Validity coefficients show that QLIS-scales differ empirically from present QoL instruments. QLIS, therefore, offers an opportunity for specific, comprehensive and reliable self-reported evaluation of QoL in schizophrenia.

Specific cognitive deficits in a group at genetic high risk of schizophrenia

“…These results therefore suggest that there are specific cognitive deficits in those at genetic HR for schizophrenia which relate to the genetic vulnerability present in HR individuals. We are aware of previous studies that have examined neuropsychological functioning using the CANTAB in those in the prodromal stage of psychosis (Wood et al 2003 ;Bartok et al 2005) but believe that this is the first study to use these tests in those at genetic HR of schizophrenia. Previous neuropsychological findings have shown spatial working memory deficits to be present in schizophrenia (e.g.…”