Cancer nanotheranostics, integrating both diagnostic and therapeutic functions into nanoscale agents, are advanced solutions for cancer management. Herein, a light‐responsive biodegradable nanorattle‐based perfluoropentane‐(PFP)‐filled mesoporous‐silica‐film‐coated gold nanorod (GNR@SiO2‐PFP) is strategically designed and prepared for enhanced ultrasound (US)/photoacoustic (PA) dual‐modality imaging guided photothermal therapy of melanoma. The as‐prepared nanorattles are composed of a thin mesoporous silica film as the shell, which endows the nanoplatform with flexible morphology and excellent biodegradability, as well as large cavity for PFP filling. Upon 808 nm laser irradiation, the loaded PFP will undergo a liquid–gas phase transition due to the heat generation from GNRs, thus generating nanobubbles followed by the coalescence into microbubbles. The conversion of nanobubbles to microbubbles can improve the intratumoral permeation and retention in nonmicrovascular tissue, as well as enhance the tumor‐targeted US imaging signals. This nanotheranostic platform exhibits excellent biocompatibility and biodegradability, distinct gas bubbling phenomenon, good US/PA imaging contrast, and remarkable photothermal efficiency. The results demonstrate that the GNR@SiO2‐PFP nanorattles hold great potential for cancer nanotheranostics.
Combined
therapy provides a more effective method in the treatment
of tumors and becomes a research hotspot. To improve treatment outcomes
and reduce serious side effects, hydrogel-based local delivery was
developed herein to form a drug depot in suit to eliminate tumors.
Indocyanine green and imiquimod were coencapsulated in the novel temperature-sensitive
chitosan hydrogel. After intratumoral injection of the hydrogel, indocyanine
green that accumulated in the tumor area could induce thermal ablation
of primary tumors under laser irradiation. In the presence of imiquimod,
the immune effects increased the probability of complete ablation
of primary tumors and inhibition of metastases. Combined with cyclophosphamide,
the enhanced immunological responses would further inhibit tumors
and prolong the survival time. In a word, this work offered an excellent
local delivery platform that enabled a remarkable combined antitumor
strategy and achieved synergistic therapeutic effects.
Multimodality imaging-guided therapy can improve the diagnostics and therapeutics efficiency of cancer. Herein, we developed a light-responsive nanotheranostic agent based on the indocyanine green (ICG) conjugated mesoporous silica coated gold nanobipyramid (GNB@SiO 2 ) (denoted as GNB@SiO 2 -ICG) for simultaneous fluorescence (FL)/photoacoustic (PA) imaging-guided photothermal therapy (PTT). The GNB@SiO 2 with excellent photostability was used for PA imaging as well as PTT. The loaded ICG promised FL imaging and PTT. The feasibility of the cancer theranostic capability of GNB@SiO 2 -ICG was evaluated from cancer cells to mice. Under the guidance of FL/PA imaging, GNB@SiO 2 -ICG exhibited remarkably enhanced therapeutic efficacy, which could eliminate the tumor tissues completely without tumor recurrence. This well-defined nanotheranostic nanoplatform that intelligently integrates dual-modality imaging and phototherapy provides an efficient nanoplatform for cancer nanotheranostics.
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