Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy

Mei, Enci; Li, Shukun; Song, Jingwen; Xing, Ronge; Li, Zhiming; Yan, Xuehai

doi:10.1016/j.colsurfa.2019.06.023

Cited by 92 publications

(30 citation statements)

References 55 publications

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“…The rational integration of PTT and immunotherapy not only inhibits the primary tumor growth but also suppresses the distant tumor growth by activating the host antitumor immunity. [ 208–212 ] For instance, chitosan‐coated hollow CuS nanoparticles assembled with immunoadjuvants oligodeoxynucleotides containing the cytosine‐guanine (CpG) motifs for synergistic photothermal immunotherapy against breast cancer on mouse model. [ 213 ] The typical photothermal effect of CuS component not only inhibited the primary tumor growth, but also released the tumor antigens, and the immunoadjuvants initiated the host antitumor immunity to suppress the distant untreated tumor growth.…”

Section: Cu‐involved Nanoagents For Synergistic Nanotherapeuticsmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

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Section: Cu‐involved Nanoagents For Synergistic Nanotherapeuticsmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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“…[97] In addition to the investigations on targeting the cancer cells, immunotherapy can also be carried out along with the photothermal cancer treatment by IHs. For example, Mei et al [98] loaded the photothermal drug methylene blue and the immunological agent imiquimod (R837) within the collagen/alginate IH with shear-thinning property that was prepared by co-assembly of positively charged collagen and negatively charged alginate. The researchers found that PTT, following intratumoral injection of the collagen/alginate hydrogel resulted in the initiation of the tumorassociated antigens (TAA) related immune responses.…”

Section: Ihs For Combination Therapy Of Cancermentioning

confidence: 99%

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Poustchi

Amani

Ahmadian³

et al. 2020

Adv Healthcare Materials

113

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The complexity of hard-to-treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve the efficiency of available treatment options. The advantages of combination therapy include the possibility of synchronous alteration of different biological pathways, reducing the required effective therapeutic dose, reducing drug resistance, and lowering the overall costs of treatment. The tunable physical properties, excellent biocompatibility, facile preparation, and ease of administration with minimal invasiveness of injectable hydrogels (IHs) have made them excellent candidates to solve the clinical and pharmacological limitations of present systems for multitherapy by direct delivery of therapeutic payloads and improving therapeutic responses through the formation of depots containing drugs, genes, cells, or a combination of them in the body after a single injection. In this review, currently available methods for the design and fabrication of IHs are systematically discussed in the first section. Next, as a step toward establishing IHs for future multimodal synergistic therapies, recent advances in cancer combination therapy, wound healing, and tissue engineering are addressed in detail in the following sections. Finally, opportunities and challenges associated with IHs for multitherapy are listed and further discussed.

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“…Combining different treatments to enhance the immune response is needed for current development. [64] Because supramolecular peptide assemblies have different structures, chemotherapeutic drugs or photosensitizing drugs can be loaded together with immune drugs to form nanoparticles, which are more stable and adaptive in the body, significantly improving drug utilization and immune efficacy. [65] In this section, we focus on the important role of supramolecular peptide assemblies in combination of cancer immunotherapy.…”

Section: Combined Supramolecular Peptide Immunotherapymentioning

confidence: 99%

Supramolecular Immunotherapy of Cancer Based on the Self‐Assembling Peptide Design

Chang

Yan

2020

Small Structures

Self Cite

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Supramolecular peptide assemblies with specific motifs have the advantages of high immunogenicity, regulated immune response, and increased multiple functions in improving the performance of cancer immunotherapy, compared with molecular peptide immunotherapy. These peptide-based assemblies with structural and functional versatility can serve as immunotherapeutic agents such as antigens, adjuvants, drug delivery carriers, or immunomodulators. This article reviews the effects of supramolecular peptide assemblies on cancer immunotherapy and highlights the unique role of supramolecular assembly strategies in regulating the immunotherapeutic performance. The mechanism of how the peptide supramolecular self-assembly affects the performance of immunotherapy is critically emphasized. The summary of peptide supramolecular immunotherapy provides a reference for the precise design of adjustable and multifunctional immunotherapeutic agents, and shows that peptide self-assembly has great application prospects in cancer immunotherapy.

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Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy

Cited by 92 publications

References 55 publications

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Supramolecular Immunotherapy of Cancer Based on the Self‐Assembling Peptide Design

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