Light‐Responsive Biodegradable Nanorattles for Cancer Theranostics

Abstract

Cancer nanotheranostics, integrating both diagnostic and therapeutic functions into nanoscale agents, are advanced solutions for cancer management. Herein, a light‐responsive biodegradable nanorattle‐based perfluoropentane‐(PFP)‐filled mesoporous‐silica‐film‐coated gold nanorod (GNR@SiO2‐PFP) is strategically designed and prepared for enhanced ultrasound (US)/photoacoustic (PA) dual‐modality imaging guided photothermal therapy of melanoma. The as‐prepared nanorattles are composed of a thin mesoporous silica film as the shell, which endows the nanoplatform with flexible morphology and excellent biodegradability, as well as large cavity for PFP filling. Upon 808 nm laser irradiation, the loaded PFP will undergo a liquid–gas phase transition due to the heat generation from GNRs, thus generating nanobubbles followed by the coalescence into microbubbles. The conversion of nanobubbles to microbubbles can improve the intratumoral permeation and retention in nonmicrovascular tissue, as well as enhance the tumor‐targeted US imaging signals. This nanotheranostic platform exhibits excellent biocompatibility and biodegradability, distinct gas bubbling phenomenon, good US/PA imaging contrast, and remarkable photothermal efficiency. The results demonstrate that the GNR@SiO2‐PFP nanorattles hold great potential for cancer nanotheranostics.

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

“…By contrast, the PA signal intensity of tumor region significantly increased after intravenous injection of PEGylated Ta NPs. The signal reached the maximum at 8 h after injection and the corresponding quantitative intensity of tumor region at 8 h was about 2.2‐fold higher than that of preinjection (Figure c), suggesting that Ta NPs were gradually accumulated in tumor section through enhanced permeability and retention (EPR) effect (Figure b), in which nanoparticles can permeate into tumor tissue through large vascular wall space and accumulate in tumor section due to the absence of lymphatic system 3a,32. The accumulated Ta NPs could obviously enhance the PA signal intensity of tumor section, which is beneficial for precise observation of tumor contour.…”

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

“…In contrast, the hydrophilic PFP-loaded HMONs (PFP@HMONs) can be well dispersed in PBS ( Figure S4b, Supporting Information), indicating that PFP could be loaded into the HMONs. [23] The nearinfrared fluorescence dye ICG was then additionally loaded into the PFP@HMONs (yielding ICG/PFP@HMONs). [23] The nearinfrared fluorescence dye ICG was then additionally loaded into the PFP@HMONs (yielding ICG/PFP@HMONs).…”

“…Ultrasound (US) is one such technique, and has advantages of bedside availability and allowing real-time imaging. [23] Even so, US imaging is not suitable for the early diagnosis of cancer due to its inherently poor contrast and limited spatial resolution. However, most of the bubbles are micrometer-sized and their lifetime in vivo is short (<20 min).…”

Gold Nanorattles with Intense Raman In Silica Nanoparticles (Nano‐IRIS) as Multimodal System for Imaging and Therapy

“…The rapid progress in the application of nanotechnology for cancer diagnosis and treatment can be attributed to the integrated imaging and therapy using various theranostic platform. [1][2][3] In this regard, hybrid colloids consisting of plasmonic metal cores and silica shells are being investigated for different sensing, imaging and therapeutic applications. [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17] Gold is the most preferred and widely used plasmonic material for biomedical applications because of its inertness and compatibility to biological system.…”