ron-deficiency anemia (IDA) is anemia due to insufficient iron. It is one of the major causes of morbidity and mortality worldwide affecting people of all ages in both developed and developing countries. The present study aims to investigate the role of oxidative/antioxidant status in the pathogenesis of IDA through a case study on children of Qalyubiyya and Minoufiya Governorates, Egypt. 119 with IDA and 150 healthy control, boys and girls, infants and young children, aged zero months to 6 years, were selected for the study from Rural Health Units and Maternity and Child Care Centers, Qalyubiyya and Minoufiya Governorates, Egypt. Based on hematological and biochemical analysis, the mean hemoglobin (Hb) level, mean corpuscular volume (MCV), reticulocyte hemoglobin content, serum iron and serum ferritin were significantly lower in infants and young children with IDA than healthy control. The opposite direction was observed for the red blood cell distribution width (RDW). The antioxidant defense system parameters including [enzymes (glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Rd; superoxide dismutase, SOD and catalase, CAT) activities and none-enzymatic levels (glutathione, GSH and vitamins A, C and E)] of infants and young children with IDA were significantly (P≤0.05) lower. While the oxidative stress parameters thiobarbituric acid reactive substances, TBARS and nitric oxide, NO2 were significantly higher than the control group. In conclusion, oxidant / antioxidant status may play a role in the Pathogenesis of Iron-Deficiency Anemia.
The present study aims to explore the effect of three byproducts that result from food processing processes, namely onion and bananas peels, and apricot seeds on neurological and immunological disorders of obese rats. Feeding of rats on diet induced obesity (DIO) leads to increase the BW than the control group. At the end of the experiment (8 weeks), rats of the normal group recorded 131.33% of baseline for the BW while obese group was 197.25% of baseline. Replacement of diets starch with banana peel powder (BPP), onion skin powder (OSP), apricot seeds powder (ASP) and their mixture induced significant decreasing on BW of the obese rats which recorded 177.85, 155.41, 173.59 and 144.83% of baseline, respectively. The higher effect on weigh decreasing was recorded for the plant parts mixtures followed by OSP, ASP and BPP, respectively. On the other side data has demonstrated the potency of the selected food processing byproducts including BPP, ROSP, ASP and their mixture to ameliorate the neurological (dopamine and serotonin content and acetylcholine esterase activity) and immunological (serum albumin and tumor necrosis factorα content, and protease activity) disorders in obese rats. These findings provide a basis for the use of the selected food processing byproducts for the prevention and early treatment of obesity. Also, the data support the benefits of dietary modification, including food processing byproducts supplementation, in alleviating neurological and immunological disorders associated obesity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.