Background Retinopathy of prematurity (ROP) is the main causeof visual impairment in premature infants. Due to advances inneonatal care, the increased survival of extremely low birth weight(ELBW) infants in recent years has produced a population ofinfants at very high risk of ROP.Objective The aims of this study were to determine theprevalence and potential risk factors for ROP.Methods This retrospective study was conducted at theNeonatalogy Ward, Cipto Mangunkusumo Hospital, fromJanuary 2005 to August 2010. We included all prematureinfants of gestational age (GA) < 37 weeks, body weight(BW) not exceeding 2000 grams, as well as those who hadeye examinations and complete medical records. Risk factorssuch as GA, BW, duration of oxygen (Oz) therapy, sepsis, andred blood cell (RBC) transfusion were analyzed using the Chi􀀻square and logistic regression tests. Pediatric ophthalmologistshad performed eye examinations on all infants. ROP was gradedaccording to the International Classification of ROP.Results The prevalence of ROP and of stage 3 or greaterROP was 11.9% and 4.8% of all subjects, respectively. Bodyweight, GA, duration of Oz therapy, and sepsis were found tobe associated with the development ofROP. However, stepwiselogistic regression analysis revealed that only BW of:s 1000g [odds ratio (OR) 10.88; 95% CI 3.09 to 38.31; P < 0.000],02 therapy 2: 7 days (OR 5.56; 95% CI 1.86 to 16.58; P <0.0001), and GA of oS 28 weeks (OR 4.26; 95% CI 1.15 to15.81; P = 0.030) were statistically significant risk factors forROP. The equation obtained was y 􀀃 -4.092 + 2.388 (BW)+ 1.451 (GA) + 1.716 (duration of 02 therapy). The modelshowed good calibration (a non􀀻significant Hosmer􀀻Lemeshowtest; P = 0.816) and discriminative ability. The area underthe curve (AUC) value was 92.2% (95% CI 0.867 to 0.976;P < 0.0001).Conclusion Prevalence ofROP in this study (11.9%) was lowerthan that of previous studies. By regression logistic analysis, themain risk factors for development ofROP were BW of:s 1000g, Oz therapy 2: 7 days, and GA :s 28 weeks. The probability ofROP occurrence increased v.ith greater number of risk factors.[Paediatr rndones. 2012;52:138-44].

Background: Injection of Silicon oil (SO) is a standard procedure for vitreous replacement in vitrectomy procedure for retinal detachment cases. It acts as a great tamponading agent for reattachment of retinal breaks or retinal detachment. Despite its minor side effect, SO could cause several complications such as cataract, endothelial decompensation, increased intraocular pressure, and secondary glaucoma. Thus needed to be evacuated after the retinal reattachment is stabilized. Following the evacuation procedure, visual acuity is known to be significantly improved. However, some cases show decreased of visual acuity due to retinal redetachment, optic nerve damage due to secondary glaucoma, hypotony, vitreous hemorrhage, expulsive hemorrhage, and cornea abnormality. Methods: A retrospective descriptive study of retinal detachment patients underwent SO evacuation procedure in Cipto Mangunkusumo Hospital,Results: There were seventy-seven cases of retinal detachment undergoes SO evacuation within the period of September 2017-January 2018. There was an improvement of visual acuity (greater than 6/60) after one month of SO evacuation. Anatomical retinal reattachment was successfully observed in 91% patient. The most occurring complication after SO evacuation includes secondary glaucoma and retinal redetachment.Conclusion: SO evacuation is a standard procedure following a vitrectomy in retinal detachment cases. The evacuation procedure yields in positive benefit for patient in term of visual acuity and anatomical structure.

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Introduction: to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy).Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR). In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment.Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45. Conclusion :Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35).

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Introduction: Endophthalmitis is an inflammation of the intraocular tissues and fluid, and an emergency in ophthalmology. One of the most common causes of endophthalmitis is post-traumatic endophthalmitis. Post-traumatic endophthalmitis has a poorer prognosis than post-cataract surgery endophthalmitis. The immediate pars plana vitrectomy (PPV) surgery in post-traumatic endophthalmitis is beneficial for optimizing of final visual. Methods: A retrospective descriptive study of post-traumatic endophthalmitis patients underwent pars plana vitrectomy in the Ciptomangunkusumo Hospital, Indonesia from January 2017 – June 2017. Result: There were twelve cases of post-traumatic endophthalmitis undergoes pars plana vitrectomy within the period of January 2017-June 2017. The most frequently identified causative organism was Staphylococcus (33,3%). There was an improvement of final visual acuity after the procedure of pars plana vitrectomy in 58.3% post-traumatic endophthalmitis patients. Conclusion: Early PPV leads to vision improvement and maintains visual acuity in post-traumatic endophthalmitis. Keywords: Pars Plana Vitrectomy, Endophthalmitis, Post-traumatic

Introduction: This study aims to determine the anatomical and functional outcomes in patients with macular hole (MH) underwent vitrectomy with internal limiting membrane (ILM) peeling. Method: A descriptive retrospective study at Vitreoretinal Division of Ophthalmology Department, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo National General Hospital (FKUI-RSCM). Secondary data obtained from medical records of patient with MH within January – December 2017. The anatomical outcome was observed from the closure of MH. Functional outcome was observed from post-operative visual acuity at day-1, month-1, month-3, and month-6. Results: 16 patients who met the criteria were included in this study. MH closure was observed in 43.8% of cases and failed closure in 56.2%. Improvement of visual acuity was observed on closure cases in 3 months and 6 months, occurred in 71.43% and 100% of cases, respectively. Conclusion: MH closure rate was 43.8%. Satisfying result of improvement in visual acuity achieved after vitrectomy with ILM peeling.

Introduction: Diabetic Macular Edema (DME) is a manifestation of diabetic retinopathy and is the most common cause of vision loss in diabetics. The incidence of DME has a tendency to increase, concomitant with the prevalence of diabetes globally by more than 50% from 2000 to 2030. This study aims to evaluate the proportion of central macular thickness (CMT) improvement and visual acuity in DME patients treated with intravitreal bevacizumab (IVB) injection. Methods: This study is a retrospective descriptive study. The study was conducted in the Department of Ophthalmology at RSUP Cipto Mangunkusumo (RSCM) Jakarta. Data were obtained from the medical records of all diabetic retinopathy patients with macular edema who were treated with IVB at RSCM Kirana Vitreoretina Polyclinic on January – December 2017. Results: Of the 44 subjects, improvement in best corrected visual acuity (BCVA) occurred in 24 (54.54%) subjects at the first-month evaluation and 19 (43.18%) subjects at the third-month evaluation. CMT decreased in 37 (84.41%) subjects at the first-month evaluation and 35 (81.81%) subjects at the third-month evaluation. Conclusion: Visual acuity improvement and central macular thickness reduction 3 months after IVB injection. These results strengthen IVB injection to be an alternative to adjuvant therapy in DME.   Keywords: Diabetic Macular Edema, Intravitreal Bevacizumab Injection