Animals from a colony of spontaneously diabetic insulin-dependent BB rats were fed from weaning with semi-synthetic diets in which natural proteins were replaced by l-amino acids with or without the addition of either milk or wheat proteins. The normal 50% incidence of diabetes in the colony was reduced to 15% in rats fed the basic semi-synthetic diet, while it was 35% and 52% when supplemented with gluten or milk, respectively. Thus, dietary factors might precipitate the expression of the disease.
Sign languages are the native languages for many pre-lingually deaf people and must be treated as genuine natural languages worthy of academic study in their own right. For such pre-lingually deaf, whose familiarity with their local spoken language is that of a second language learner, written text is much less useful than is commonly thought. This paper presents research into sign language generation from English text at the University of East Anglia that has involved sign language grammar development to support synthesis and visual realisation of sign language by a virtual human avatar. One strand of research in the ViSiCAST and eSIGN projects has concentrated on the generation in real time of sign language performance by a virtual human (avatar) given a phonetic-level description of the required sign sequence. A second strand has explored generation of such a phonetic description from English text. The utility of the conducted research is illustrated in the context of sign language synthesis by a preliminary consideration of plurality and placement within a grammar for British Sign Language (BSL). Finally, ways in which the animation generation subsystem has been used to develop signed content on public sector Web sites are also illustrated
Aims/hypothesis. The diabetes-inducing potential of cows' milk is still debated and there is no consensus on the diabetogenicity of individual milk proteins. A 1 -β-casein has been associated with increased diabetes frequency in ecological studies and in NOD mice. Our aim was to ascertain whether A 1 -β-casein was more diabetogenic than A 2 and to test the diabetogenicity of a milk-free diet in animals representing different forms of spontaneous Type I (insulin-dependent) diabetes mellitus. Methods. Defined diets were coded and shipped to laboratories in New Zealand (NOD/NZ), Canada (BB) and the UK (NOD/Ba). Base diets were Pregestimil (PG) and ProSobee (PS). Purified fractions of whole casein (WC), A 1 or A 2 -β-casein were added at 10%. A milk-free, wheat-predominant, NTP-2000 diet was the control. Animals were fed from weaning up to 150 or 250 days, and insulitis, diabetes frequency and expression of pancreatic cytokines were assessed. Results. Diabetes incidence was highest in three locations in animals fed NTP-2000. PG and PS diets were protective except for NOD/Ba mice fed PG+WC where incidence was similar to NTP-2000. A 1 and A 2 diets were protective in both models, but A 1 β-casein was slightly more diabetogenic in PS-fed BB rats. The New Zealand study was confounded by an infection. Conclusion/interpretation. A milk-free, wheat-predominant diet was highly diabetogenic in three widely separate locations in both animal models. A previous result that A 1 β-casein was more diabetogenic than A 2 β-casein in NOD mice was not confirmed; both β-casein variants were protective in BB rats and NOD mice. Whole Casein promoted diabetes in NOD/Ba but protected BB showing that unique diabetes haplotypes react differently to dietary proteins. A 1 -was more diabetogenic than A 2 -β-casein only in PS-fed BB rats. Neither the analysis of insulitis nor of pancreatic cytokine gene expression showed a difference between A 1 or A 2 β-casein fed animals. Milk caseins are unlikely to be exclusive promoters of Type I diabetes, but could enhance the outcome of diabetes in some cases. Other diet components such as wheat could be more important promoters of Type I diabetes. [Diabetologia (2002[Diabetologia ( ) 45:1240[Diabetologia ( -1246
Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially other influencing factors underpins disease progression. We present evidence that A1 β-casein cows’ milk protein is a primary causal trigger of type 1 diabetes in individuals with genetic risk factors. Permissive gut factors (for example, aberrant mucosal immunity), intervene by impacting the gut’s environment and the mucosal barrier. Various influencing factors (for example, breastfeeding duration, exposure to other dietary triggers and vitamin D) modify the impact of triggers and permissive gut factors on disease. The power of the dominant trigger and permissive gut factors on disease is influenced by timing, magnitude and/or duration of exposure. Within this framework, removal of a dominant dietary trigger may profoundly affect type 1 diabetes incidence. We present epidemiological, animal-based, in vitro and theoretical evidence for A1 β-casein and its β-casomorphin-7 derivative as dominant causal triggers of type 1 diabetes. The effects of ordinary milk containing A1 and A2 β-casein and milk containing only the A2 β-casein warrant comparison in prospective trials.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.