Dietary protein: a trigger of insulin-dependent diabetes in the BB rat?

Rb, Elliott; Martin, Joseph V.

doi:10.1007/bf00283653

Cited by 188 publications

(104 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A detailed study of infant feeding patterns indicated that the age at introduction of dairy products had the closest association with the risk of IDDM when the duration of both overall and exclusive breast-feeding was taken into account [8]. This is in accordance with previous studies [9,10] which showed that the early introduction of dairy products increased the incidence of diabetes in diabetes-prone Bio Breeding rats. Further, increased levels of antibodies to cow's milk formula, BLG and BSA have been observed in newly-diagnosed diabetic children [5,[11][12][13].…”

supporting

confidence: 87%

Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children

et al. 1994

View full text Add to dashboard Cite

Summary Associations of infant feeding patterns and milk consumption with cow's milk protein antibody titres were studied in 697 newly-diagnosed diabetic children, 415 sibling-control children and 86 birth-dateand sex-matched population-based control children in the nationwide "Childhood Diabetes in Finland" study. IgA and IgG antibody titres to the proteins of cow's milk formula, BLG and BSA, and IgM antibody titres to cow's milk formula proteins were measured by ELISA. Several inverse correlations were observed between the duration of breast-feeding or age at introduction of dairy products and antibody titres, and positive correlations were observed between milk consumption and antibody titres in all three populations studied. Multivariate analyses which included the infant feeding variables, milk consumption and current age simultaneously showed that the earlier the introduction of dairy products and the greater the consumption of milk was, the higher several antibody titres were. High IgA antibody titres to cow's milk formula were associated with a greater risk of IDDM both among diabeticpopulation-control and diabetic-sibling-control pairs when adjusted for other cow's milk antibody titres, dietary variables and in diabetic-sibling-control pairs also for ICA. The results suggest that young age at introduction of dairy products and high milk consumption during childhood increase the levels of cow's milk antibodies and that high IgA antibodies to cow's milk formula are independently associated with increased risk of IDDM. [Diabetologia (1994) 37: 381-387]

show abstract

supporting

confidence: 87%

Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children

et al. 1994

View full text Add to dashboard Cite

show abstract

“…Experiments in BB rats [16] and NOD mice [17] have clearly demonstrated a deleterious effect of various complex foreign-protein weaning diets in the disease process. The strongest indirect evidence in man for an association between early exposure to dietary CM proteins and the risk of type 1 diabetes comes from epidemiological studies of infant feeding, with an inverse correlation between the duration of breastfeeding and the incidence of type 1 diabetes in childhood (reviewed in [1][2][3]).…”

Section: Discussionmentioning

confidence: 99%

Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study

et al. 2005

View full text Add to dashboard Cite

Aims/hypothesis: We aimed to assess the feasibility of a dietary intervention trial with weaning to hydrolysed formula in infants at increased risk of type 1 diabetes and to study the effect of the intervention on the emergence of diabetes-associated autoantibodies in early childhood. Methods: We studied 242 newborn infants who had a first-degree relative with type 1 diabetes and carried risk-associated HLA-DQB1 alleles. After exclusive breastfeeding, the infants underwent a double-blind, randomised pilot trial of either casein hydrolysate (Nutramigen; Mead Johnson) or conventional cow's milk-based formula until the age of 6-8 months. During a mean observation period of 4.7 years, autoantibodies to insulin, anti-glutamic acid decarboxylase and insulinoma-associated antigen-2 were measured by radiobinding assays, and islet cell antibodies (ICA) by immunofluorescence. Results: The feasibility of screening and identifying a cohort of first-degree relatives with HLA-conferred disease susceptibility, enrolling them in a dietary intervention trial and following them for seroconversion to autoantibody positivity is established. The

show abstract

“…The relation between short duration of total breastfeeding and early exposure to cows' milk proteins with increased risk of Type I diabetes has been shown by a number of studies in humans [33] and in animal models [34,35]. Duration of breastfeeding also modulates, however, the incidence and prevalence of infections early in life.…”

mentioning

confidence: 99%