to explore the potential neurobiological basis for the improvement of neurocognitive function. Methods: We recruited 12 patients with OSA after stroke who received a diagnosis using overnight polysomnography (PSG) with apneahypopnea index (AHI) > 10. Patients were randomly divided into two groups (randomized single blind controlled trial) : electroacupuncture group and sham acupuncture group. Observing the two groupsKarolinska Drowsiness Test (KDT) (awake EEG measurement with eyes open and closed)、Overnight polysomnography (PSG) 、Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) before and after the treatment. KDT tests were performed every 2 h from 08:00 to 14:00 (four sessions).Electroacupuncture group was treated by acupuncturingSishencong (EX-HN1) points, sham acupuncture group received acupuncture non acupoint therapy which is besides Sishencong (EX-HN1) 0.5 cm, were treated for 15 days, once a day.Resting awake EEG was recorded during a KDT, which comprised repeated sessions of 7.5-min EEG recordings. Each 7.5-min session started with a 2.5-min eyes-open time, then 2.5-min eyes closed, then another 2.5-min of eyes open. Thirty seconds at the beginning of each 2.5-min segment were discarded from analysis to avoid the artefact caused by patients settling to the new task after being instructed to change behavior. The PSG system (Philip compumedics, E-Series, Australia) was used with a sampling rate of 200 Hz. EEG recording channels included C3-M2, C4-M1, F4-M1, F3-M2, O2-M1, O1-M2, left and right electrooculogram (EOG) and Karolinska Sleepiness Scale (KSS).Result:Compared to sham acupuncture group, electroacupuncture group increased awake EEG activation (faster EEG frequency) with increased alpha/delta (A/D) ratio (P < 0.05) and fast ratio = (alpha+beta)/(delta+theta) (P < 0.05) across the OSA patientsafterstroke. The A/D ratio signifcantly correlatedwith MMSE and MoCA. Compared with sham acupuncture group, daytime sleepiness was significantly improved in electroacupuncture group (P < 0.01).Conclusion: Electroacupuncture increased awake EEG activation, whichcorrelated to improved performance. This study provides supporting neurophysiological evidence that electroacupuncture is a potential treatmentoption on OSA after stroke.
Currently there is an active search for medicines increasing the stability of liver to pathological effects, reinforcing its neutralizing function, promoting its functional recovery after various injuries, including poisoning by industrial poisons. Therefore, the study of opportunities to reduce toxic liver damage by carbon tetrachloride introduction of synthetic and natural antioxidants is of interest. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the introduction of the succinate containing drug called Reamberin (Polysan, St.Petersburg) and licorice syrup. The animals were divided into 4 groups and each of them had 10 rats: the group with intact animals which were held in standard conditions of vivarium; the control group in which rats were given carbon tetrachloride during 3 days daily; the experimental group in which before the introduction of carbon tetrachloride animals had a daily intra-abdominal intake of the Reamberin in a dose of 100 mg/kg (20 ml/kg); the experimental group in which before the introduction of carbon tetrachloride animals had a daily oral intake of the licorice syrup in a dose of 5 ml/kg. It was found out that in the blood and in the liver of experimental animals an introduction of carbon tetrachloride during 3 days contributes to the increase of lipid hydroperoxides level (by 24-43%), of diene conjugate (by 19-47%), and of malonic dialdehyde (by 61-81%) against the decrease of antioxidant system activity in the blood of intact animals. The introduction of the succinate containing drug to rats in the conditions of oxidative stress contributes to the decrease in the blood and in the liver of lipid hydroperoxides by 13-26%, of diene conjugates by 11-28%, and of malonic dialdehyde by 30-34% in comparison with the rats of the control group. Adding of the licorice syrup to rats contributes to the reliable decrease in the blood and in the liver of lipid hydroperoxides by 6-23%, of diene conjugates by 9-24%, and of malonic dialdehyde by 25-30% in comparison with the rats of the control group. While analyzing the effect of the antioxidants on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood and in the liver of animals was reliably higher by 10-47%, of vitamin E by 13-42% in comparison with the same parameters of the rats of the control group. So, the application of the synthetic and natural antioxidants in the conditions of introduction of carbon tetrachloride of the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.
Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия» Министерства здравоохранения Российской Федерации, 675000, г. Благовещенск, ул. Горького, 95 РЕЗЮМЕ Поиск и разработка способов коррекции окисли-тельного стресса в условиях воздействия неблаго-приятных факторов окружающей среды являются актуальной проблемой современной медицины. В экспериментальных условиях исследована возмож-ность коррекции свободнорадикального окисления липидов мембран организма крыс наружным при-менением мази травы вьюнка и мази травы звезд-чатки. Животные были разделены на 4 группы, в каждой по 20 крыс: интактные животные, которые содержались в стандартных условиях вивария; контрольная группа, где крысы подвергались воз-действию ультрафиолетового облучения в течение 3 минут ежедневно; подопытная группа, где живот-ным перед ультрафиолетовым облучением еже-дневно применяли мазь травы вьюнка; подопытная группа, где животным перед ультра-фиолетовым облучением ежедневно применяли мазь травы звездчатки. Установлено, что ежеднев-ное ультрафиолетовое облучение в течение трех минут способствует повышению содержания гидро-перекисей липидов (на 15-19%), диеновых конъю-гатов (на 14-16%), малонового диальдегида (на 40-66%) на фоне снижения активности основных компонентов антиоксидантной системы. Примене-ние мази травы вьюнка и мази травы звездчатки в условиях окислительного стресса способствует до-стоверному снижению в плазме крови гидропереки-сей липидов на 9-13%, диеновых конъюгатов -на 8-13%, малонового диальдегида -на 15-28% по сравнению с крысами контрольной группы. При анализе влияния мазей на активность компонентов антиоксидантной системы было установлено, что содержание церулоплазмина в крови животных было достоверно выше аналогичного показателя у крыс контрольной группы на 13-20%, витамина Е -на 8-14%, каталазы -на 13-28%. Таким образом, использование мази травы вьюнка и мази травы звездчатки в условиях окислительного стресса, ин-дуцированного воздействием ультрафиолетовых лучей, приводит к стабилизации процессов перок-сидации на фоне повышения активности основных компонентов антиоксидантной системы. The search and development of methods for correction of oxidative stress in conditions of exposure to adverse environmental factors is an actual problem of modern medicine. In experimental conditions the possibility to correct free radical lipid oxidation of rats' cell membranes was studied with the external application of the ointment of herb convolvulus and of the ointment of herb chickweed. The animals were divided into 4 groups and each of them had 20 rats: intact animals which were held in standard conditions of vivarium; the control group in which rats were exposed to ultraviolet radiation during three minutes daily; the experimental group in which before ultraviolet radiation animals had a daily external application of the ointment of herb convolvulus; the experimental group in which before ultraviolet radiation animals had a daily external application of th...
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